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Open AccessGenetic and metabolic predictors of chemosensitivity in oligodendroglial neoplasms
The −1p/−19q genotype predicts chemosensitivity in oligodendroglial neoplasms, but some with intact 1p/19q also respond and not all with 1p/19q loss derive durable benefit from chemotherapy. We have evaluated ...
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APC mutation analysis by chemical cleavage of mismatch and a protein truncation assay in familial adenomatous polyposis
Overall, the causative APC mutation has been identified in only 30% of the patients with familial adenomatous polyposis (FAP) who have been included in studies reported in the literature. In order to determine...
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Article
Exclusion of constitutional p53 mutations as a cause of genetic susceptibility to colorectal cancer
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Constitutional p53 mutation in a non-Li-Fraumeni cancer family
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Mutations in p53 do not account for heritable breast cancer: a study in five affected families