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Article
Lack of mature lymphocytes results in obese but metabolically healthy mice when fed a high-fat diet
Obesity is characterized by chronic inflammation and immune dysregulation, as well as insulin resistance, but the link between obesity and adaptive immunity remains to be fully studied.
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Article
Lack of Day/Night variation in fibroblast growth factor 21 levels in young healthy men
Fibroblast growth factor (FGF) 21 is an endocrine factor with an emerging role as a metabolic regulator. We previously reported the presence of a significant day/night variation of FGF-21 in energy-replete, he...
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Article
Circulating irisin levels and coronary heart disease: association with future acute coronary syndrome and major adverse cardiovascular events
Irisin is a newly discovered myokine, associated with 'browning' of the white adipose tissue, obesity, insulin resistance and metabolic syndrome. The purpose of this study is to evaluate circulating irisin as ...
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Article
Amylin and leptin activate overlap** signalling pathways in an additive manner in mouse GT1-7 hypothalamic, C2C12 muscle and AML12 liver cell lines
It has been suggested that amylin amplifies leptin’s effects and affects energy homeostasis synergistically with leptin in animals and humans. However, no previous study has reported on amylin and leptin signa...
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Article
Leptin administered in physiological or pharmacological doses does not regulate circulating angiogenesis factors in humans
Leptin has been shown to regulate angiogenesis in animal and in vitro studies by upregulating the production of several pro-angiogenic factors, but its role in regulating angiogenesis has never been studied in...
