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Article
Erratum: Excision of HIV-1 DNA by gene editing: a proof-of-concept in vivo study
Correction to: Gene Therapy advance online publication, 19 May 2016; doi: 10.1038/gt.2016.41 The following statement should be noted under Conflict of Interest: 'KK, WH, and RK are named inventors on patents t...
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Article
Excision of HIV-1 DNA by gene editing: a proof-of-concept in vivo study
A CRISPR/Cas9 gene editing strategy has been remarkable in excising segments of integrated HIV-1 DNA sequences from the genome of latently infected human cell lines and by introducing InDel mutations, suppress...
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Article
Eine Weight-of-Evidence-Studie zur Bewertung der Sedimentbelastung und des Fischrückgangs in der Oberen Donau
Hintergrund und Ziel der Studie Die Fischbestände in der Donau sind seit Ende der 1980er-Jahre stark rückläufig. Trotz intensiver bestandsstützender Maßnahmen und einer verbesserten Wasserqualität entlang der Don...
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Article
Reaktivierung nach einer Herpes-simplex-Enzephalitis
Im Falle einer Reaktivierung nach einer Herpes-simplex-Enzephalitis (HSE) ist eine klare Unterscheidung zwischen einer rekurrierenden Virusinfektion und einem Autoimmunprozess oft nicht möglich; beide pathophy...
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Article
p27SJ, a novel protein in St John's Wort, that suppresses expression of HIV-1 genome
Transcription of the HIV-1 genome is controlled by the cooperation of viral regulatory proteins and several host factors which bind to specific DNA sequences within the viral promoter spanning the long termina...
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Article
Effect of different East Coast Fever control strategies on fertility, milk production and weight gain of Sanga cattle in the Central Province of Zambia
Five different East Coast Fever (ECF) (Theileria parva infection) control strategies, based on tick control and/or ECF immunization, were tested in groups of traditionally managed Sanga cattle in the Central P...
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Article
Proteinase — Antiproteinase imbalance in meningitis: Determination of α 1 proteinase inhibitor (α 1PI), elastase — α-1PI complex, and elastase inhibition capacity in cerebrospinal fluid
Mortality and long-term neurologic sequelae are still frequent complications of meningitis despite effective antibiotic treatment. This suggests that pathogen-independent inflammatory mechanisms may play an im...
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Article
Hyperthermia in cancer therapy
Tumor hyperthermia is a rediscovered technique of oncotherapy which has confirmed value in many studies on cell cultures, rodent and mammalian tumors as well as first investigations on patients with tumors. Th...
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Article
ELASTASE-α1-PROTEINASE INHIBITOR IN NEONATAL SEPTICEMIA AND HYALINE MEMBRANE DISEASE
Elastase, a neutral protease stored in the azurophillic granules of neutrophils, is immediately released during the process of phagocytosis and rapidly bound and inactivated by α1-proteinase inhibitor. This compl...
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Chapter
Effect of Localized Hyperthermia on Tumor Blood Flow and Oxygenation
Hyperthermia has been shown to have a lethal effect in tumor cell cultures, particularly at temperatures above 42°C.1 Moreover, it has been demonstrated that hyperthermia retards the growth rate of certain types ...
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Chapter
Impact of Various Thermal Doses on the Oxygenation and Blood Flow in Malignant Tumors Upon Localized Hyperthermia
Hyperthermia exhibits various direct cytocidal effects (Dickson, 1977; Overgaard, 1977; Suit, 1977). During heat treatment in vivo, several indirect mechanisms enhance the direct cell-killing capa...
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Chapter
Relationship Between Size and Oxygenation Status of Malignant Tumors
During advanced phases of malignant growth, there are typical changes in the microvasculature pattern within the tissue of many solid tumors. Partly due to these peculiarities of tumor vascularization, a serie...
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Chapter
Impact of Localized Microwave Hyperthermia on the Oxygenation Status of Malignant Tumors
Considerable insight into the mechanisms of heat induced cell death in vitro has been gained during recent years (for reviews see 1–3). Besides the direct cell killing effect of heat, many microenvironmental or m...
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Chapter
Preoperative and Postoperative Intensive Care and Oedema Therapy
78% of our child patients with brain tumours showed signs of raised intracerebral pressure on first admission to the department. They were thus endangered patients who require subtle diagnosis. We should like ...
