-
Article
Impact of Sodium Cationization on Gas-Phase Conformations of DNA and RNA Cytidine Mononucleotides
Gas-phase conformations of the sodium-cationized forms of the 2′-deoxycytidine and cytidine mononucleotides, [pdCyd+Na]+ and [pCyd+Na]+, are examined by infrared multiple photon dissociation action spectroscopy. ...
-
Article
Structures and Relative Glycosidic Bond Stabilities of Protonated 2′-Fluoro-Substituted Purine Nucleosides
The 2′-substituent is the primary distinguishing feature between DNA and RNA nucleosides. Modifications to this critical position, both naturally occurring and synthetic, can produce biologically valuable nucl...
-
Article
Impact of the 2′- and 3′-Sugar Hydroxyl Moieties on Gas-Phase Nucleoside Structure
Modified nucleosides have been an important target for pharmaceutical development for the treatment of cancer, herpes simplex virus, and the human immunodeficiency virus (HIV). Amongst these nucleoside analogu...
-
Article
Modified Quadrupole Ion Trap Mass Spectrometer for Infrared Ion Spectroscopy: Application to Protonated Thiated Uridines
Modifications to a Paul-type quadrupole ion trap mass spectrometer providing optical access to the trapped ion cloud as well as hardware and software for coupling to a table-top IR optical parametric oscillato...
-
Article
Influence of Transition Metal Cationization versus Sodium Cationization and Protonation on the Gas-Phase Tautomeric Conformations and Stability of Uracil: Application to [Ura+Cu]+ and [Ura+Ag]+
The gas-phase conformations of transition metal cation-uracil complexes, [Ura+Cu]+ and [Ura+Ag]+, were examined via infrared multiple photon dissociation (IRMPD) action spectroscopy and theoretical calculations. ...
-
Article
IRMPD Action Spectroscopy, ER-CID Experiments, and Theoretical Studies of Sodium Cationized Thymidine and 5-Methyluridine: Kinetic Trap** During the ESI Desolvation Process Preserves the Solution Structure of [Thd+Na]+
Thymidine (dThd) is a fundamental building block of DNA nucleic acids, whereas 5-methyluridine (Thd) is a common modified nucleoside found in tRNA. In order to determine the conformations of the sodium cationi...
-
Article
N3 and O2 Protonated Conformers of the Cytosine Mononucleotides Coexist in the Gas Phase
The gas-phase conformations of the protonated forms of the DNA and RNA cytosine mononucleotides, [pdCyd+H]+ and [pCyd+H]+, are examined by infrared multiple photon dissociation (IRMPD) action spectroscopy over th...
-
Article
2,4-Dihydroxy and O2 Protonated Tautomers of dThd and Thd Coexist in the Gas Phase: Methylation Alters Protonation Preferences versus dUrd and Urd
The gas-phase structures of protonated thymidine, [dThd + H]+, and its modified form, protonated 5-methyluridine, [Thd + H]+, are examined by infrared multiple photon dissociation (IRMPD) action spectroscopy comb...
-
Article
IRMPD Action Spectroscopy of Alkali Metal Cation–Cytosine Complexes: Effects of Alkali Metal Cation Size on Gas Phase Conformation
The gas-phase structures of alkali metal cation-cytosine complexes generated by electrospray ionization are probed via infrared multiple photon dissociation (IRMPD) action spectroscopy and theoretical calculat...
-
Article
Protonation Preferentially Stabilizes Minor Tautomers of the Halouracils: IRMPD Action Spectroscopy and Theoretical Studies
Tautomerization induced by protonation of halouracils may increase their efficacy as anti-cancer drugs by altering their reactivity and hydrogen bonding characteristics, potentially inducing errors during DNA ...
-
Article
Infrared Multiple Photon Dissociation Action Spectroscopy and Theoretical Studies of Triethyl Phosphate Complexes: Effects of Protonation and Sodium Cationization on Structure
The gas-phase structures of protonated and sodium cationized complexes of triethyl phosphate, [TEP + H]+ and [TEP + Na]+, are examined via infrared multiple photon dissociation (IRMPD) action spectroscopy using t...
-
Article
Open AccessInfrared Multiple Photon Dissociation Action Spectroscopy and Theoretical Studies of Diethyl Phosphate Complexes: Effects of Protonation and Sodium Cationization on Structure
The gas-phase structures of deprotonated, protonated, and sodium-cationized complexes of diethyl phosphate (DEP) including [DEP − H]−, [DEP + H]+, [DEP + Na]+, and [DEP − H + 2Na]+ are examined via infrared multi...
-
Chapter and Conference Paper
Infrared Spectroscopy of Ionic PAHs and Related Compounds
Despite the fact that the interstellar Unidentified InfraRed emission bands (UIRs) are now widely accepted to be due to emission from (ionic) gasphase polycyclic aromatic hydrocarbons (PAHs)[1, 2], close inspe...
-
Chapter
Application of Sensitive Trace Gas Detectors in Post-harvest Research
-
Article
CO-laser-based photoacoustic trace-gas detection: applications in postharvest physiology
measurements using polarographic oxygen sensors.
