13 Result(s)

Article

Expression of Human Anti-Hemophilic Factor IX in the Milk of Transgenic Sheep

Transgenic livestock may prove useful for the large scale production of valuable proteins. By targeting expression to the mammary gland these proteins could be harvested from milk. To this end, we have designe...

A. J. Clark, H. Bessos, J. O. Bishop, P. Brown, S. Harris, R. Lathe… in Bio/Technology (1989)

Article

Messenger RNAs coding for mouse major urinary proteins are differentially induced by testosterone

We have investigated the sexual dimorphism of the mouse major urinary proteins (MUPs) by isoelectric focusing (IEF). In each of two inbred strains which have different male patterns (C57BL and BALB/c), the fem...

Patricia M. Clissold, Sheila Hainey, J. O. Bishop in Biochemical Genetics (1984)

Article

Plasmid cloning vectors that can be nicked at a unique site

We describe ColE1-type plasmids, with relaxed DNA replication, based on pMB9, and carrying the Cm^R determinant of R1, in addition to the Tc^R determinant of pMB9. One of the plasmids, pPH207, has unique sites for ...

J. O. Bishop, Jane A. Davies in Molecular and General Genetics MGG (1980)

Chapter

Analysis and Resolution of mRNA Populations

Populations of polyadenylated messenger RNA (mRNA) sequences can conveniently be characterised by studying the kinetics of hybridisation between the mRNA population and a cDNA copy population which is usually ...

J. O. Bishop, P. M. Clissold, J. A. Davis… in Genome Organization and Expression in Plan… (1980)

Chapter and Conference Paper

Is Foldback DNA Repeatedly Transposed?

Foldback DNA is DNA that forms duplexes from the single-strand (denatured) state as a result of an intramolecular event. Thus, the rate of its formation is independent of DNA concentration, unlike DNA renatura...

J. O. Bishop, C. Phillips in Integration and Excision of DNA Molecules (1978)

Article

Lampbrush chromosomes brought up to date

J. O. Bishop in Nature (1977)

Article

Three abundance classes in HeLa cell messenger RNA

Approximately 35,000 different poly(A)-containing RNA sequences are present in HeLa cell cytoplasm. The sequences are grouped in three distinct abundance classes.

J. O. Bishop, J. G. Morton, M. Rosbash, Melville Richardson in Nature (1974)

Article

Complex formation between Poly-r (U) and various chromosomal loci in Rhynchosciara

Polyribouridylic acid [poly(U)] labelled with tritium was annealed to chromosomes from Rhynchosciara salivary glands to detect the distribution of A-T rich DNA. A clear pattern of binding was observed to several ...

K. W. Jones, J. O. Bishop, A. Brito-da-Cunha in Chromosoma (1973)

Article

Chromosomal Localization of Human Haemoglobin Structural Genes

PRICE et al.¹ recently claimed to have located the structural genes for haemoglobin on human chromosomes 2 and 4 or 5 by in situ hybridization using labelled haemoglobin mRNA. We wish to warn against a too ready ...

J. O. BISHOP, K. W. JONES in Nature (1972)

Article

Scattered Arrangement of the Bacterial Ribosomal Cistrons

In two bacterial species the tandem genes coding for 23S and 16S ribosomal RNA are widely scattered, by contrast with the situation in eukaryotes.

I. PURDOM, J. O. BISHOP, M. L. BIRNSTIEL in Nature (1970)

Article

Interpretation of DNA-RNA Hybridization Data

THE mechanism of DNA–RNA hybridization is not well understood, and several different approaches to the interpretation of experimental results have been proposed. One such approach¹ seems to have gained fairly wid...

J. O. BISHOP in Nature (1969)

Article

What Histones Do

Histones

J. O. BISHOP in Nature (1967)