80 Result(s)

Article

Confirmation of novel type 1 diabetes risk loci in families

Over 50 regions of the genome have been associated with type 1 diabetes risk, mainly using large case/control collections. In a recent genome-wide association (GWA) study, 18 novel susceptibility loci were ide...

J. D. Cooper, J. M. M. Howson, D. Smyth, N. M. Walker, H. Stevens… in Diabetologia (2012)

Article

HbA_1c and mean blood glucose show stronger associations with cardiovascular disease risk factors than do postprandial glycaemia or glucose variability in persons with diabetes: the A1C-Derived Average Glucose (ADAG) study

Increased glucose excursions and postprandial hyperglycaemia have been suggested as unique risk factors for cardiovascular disease (CVD) and mortality in patients with diabetes mellitus. Much of the evidence i...

R. Borg, J. C. Kuenen, B. Carstensen, H. Zheng, D. M. Nathan, R. J. Heine… in Diabetologia (2011)

Article

Real-life glycaemic profiles in non-diabetic individuals with low fasting glucose and normal HbA_1c: the A1C-Derived Average Glucose (ADAG) study

Real-life glycaemic profiles of healthy individuals are poorly studied. Our aim was to analyse to what extent individuals without diabetes exceed OGTT thresholds for impaired glucose tolerance (IGT) and diabetes.

R. Borg, J. C. Kuenen, B. Carstensen, H. Zheng, D. M. Nathan, R. J. Heine… in Diabetologia (2010)

Article

The intrauterine metabolic environment modulates the gene expression pattern in fetal rat islets: prevention by maternal taurine supplementation

Events during fetal life may in critical time windows programme tissue development leading to organ dysfunction with potentially harmful consequences in adulthood such as diabetes. In rats, the beta cell mass ...

B. Reusens, T. Sparre, L. Kalbe, T. Bouckenooghe, N. Theys, M. Kruhøffer… in Diabetologia (2008)

Article

Post-translational protein modifications in type 1 diabetes: a role for the repair enzyme protein-l-isoaspartate (d-aspartate) O-methyltransferase?

Post-translational modifications, such as isomerisation of native proteins, may create new antigenic epitopes and play a role in the development of the autoimmune response. Protein-l-isoaspartate (d-aspartate) O-...

A. M. Wägner, P. Cloos, R. Bergholdt, P. Boissy, T. L. Andersen… in Diabetologia (2007)

Article

Increased prevalence of Down’s syndrome in individuals with type 1 diabetes in Denmark: a nationwide population-based study

In patients with Down’s syndrome, dogma has long held that the prevalence of diabetes is increased. The aim of the present study was to determine the actual prevalence of Down’s syndrome among type 1 diabetic ...

R. Bergholdt, S. Eising, J. Nerup, F. Pociot in Diabetologia (2006)

Article

To: Biason-Lauber A, Boehm B, Lang-Muritano M et al. (2005) Association of childhood type 1 diabetes mellitus with a variant of PAX4: possible link to beta cell regenerative capacity. Diabetologia 48:900–905

T. Gylvin, R. Bergholdt, J. Nerup, F. Pociot in Diabetologia (2005)

Article

Gene expression profiles during beta cell maturation and after IL-1β exposure reveal important roles of Pdx-1 and Nkx6.1 for IL-1β sensitivity

Maturation of the beta cells in the islets of Langerhans is dependent upon sequential activation of different transcription factors such as Pdx-1 and Nkx6.1. This maturation is associated with an acquired sens...

K. Nielsen, M. Kruhøffer, T. Ørntoft, T. Sparre, H. Wang, C. Wollheim… in Diabetologia (2004)

Article

Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1β-mediated toxicity through inhibition of multiple nuclear factor-κB-regulated proapoptotic pathways

The proinflammatory cytokine IL-1β induces apoptosis in pancreatic beta cells via pathways dependent on nuclear factor-κB (NF-κB), mitogen-activated protein kinase, and protein kinase C. We recently showed sup...

A. E. Karlsen, P. E. Heding, H. Frobøse, S. G. Rønn, M. Kruhøffer… in Diabetologia (2004)

Article

40^th EASD Annual Meeting of the European Association for the Study of Diabetes

M. Veitenhansl, K. Stegner, F.-X. Hierl, C. Dieterle, H. Feldmeier, B. Gutt… in Diabetologia (2004)

Article

Mutation analysis of suppressor of cytokine signalling 3, a candidate gene in Type 1 diabetes and insulin sensitivity

Beta cell loss in Type 1 and Type 2 diabetes mellitus may result from apoptosis and necrosis induced by inflammatory mediators. The suppressor of cytokine signalling (SOCS)-3 is a natural inhibitor of cytokine...

T. Gylvin, R. Nolsøe, T. Hansen, E. M. D. Nielsen, R. Bergholdt… in Diabetologia (2004)

Article

Changes in expression of IL-1β influenced proteins in transplanted islets during development of diabetes in diabetes-prone BB rats

Type 1 diabetes mellitus is a multifactorial autoimmune disease characterised by selective destruction of beta cells in the islets of Langerhans. We have previously shown that IL-1β modulates beta cell functio...

T. Sparre, U. Bjerre Christensen, C. F. Gotfredsen, P. Mose Larsen… in Diabetologia (2004)

Article

Protein expression changes in a cell system of beta-cell maturation reflect an acquired sensitivity to IL-1β

Type 1 diabetes mellitus (T1DM) is caused by specific destruction of the pancreatic beta cells in the islets of Langerhans. Increased sensitivity to cytokines, in particular to interleukin-1β (IL-1β) seems to ...

K. Nielsen, T. Sparre, M. R. Larsen, M. Nielsen, S. J. Fey, P. Mose Larsen… in Diabetologia (2004)