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  1. No Access

    Article

    Endospanin 1 silencing in the hypothalamic arcuate nucleus contributes to sustained weight loss of high fat diet obese mice

    Leptin targets specific receptors (OB-R) expressed in the hypothalamus to regulate energy balance. Leptin decreases food intake in normal weight individuals, but this effect is blunted in obese subjects who ar...

    V Vauthier, T D Swartz, P Chen, C Roujeau, M Pagnon, J Mallet, C Sarkis… in Gene Therapy (2014)

  2. No Access

    Article

    The human protein kinase HIPK2 phosphorylates and downregulates the methyl-binding transcription factor ZBTB4

    HIPK2 is a eukaryotic Serine–Threonine kinase that controls cellular proliferation and survival in response to exogenous signals. Here, we show that the human transcription factor ZBTB4 is a new target of HIPK...

    D Yamada, R Pérez-Torrado, G Filion, M Caly, B Jammart, V Devignot, N Sasai… in Oncogene (2009)

  3. No Access

    Article

    Does neuronal expression of GDNF effectively protect dopaminergic neurons in a rat model of Parkinson's disease?

    The transfer of the Glial cell line-derived neurotrophic factor (GDNF) gene to the central nervous system by a recombinant adenoviral vector (Ad) was studied. We constructed the adenovirus vector Ad-NSE-GDNF f...

    N A Do Thi, P Saillour, L Ferrero, T Paunio, J Mallet in Gene Therapy (2007)

  4. No Access

    Article

    Targeted in vivo expression of nicotinic acetylcholine receptors in mouse brain using lentiviral expression vectors

    B. E. Molles, U. Maskos, S. Pons, M. Besson… in Journal of Molecular Neuroscience (2006)

  5. No Access

    Article

    Delivery of GDNF by an E1,E3/E4 deleted adenoviral vector and driven by a GFAP promoter prevents dopaminergic neuron degeneration in a rat model of Parkinson's disease

    A new adenoviral vector (Ad-GFAP-GDNF) (Ad=adenovirus, GFAP=glial fibrillary acidic protein, GDNF=glial cell line-derived neurotrophic factor) was constructed in which (i) the E1,E3/E4 regions of Ad5 were dele...

    N A Do Thi, P Saillour, L Ferrero, J F Dedieu, J Mallet, T Paunio in Gene Therapy (2004)

  6. No Access

    Article

    Viral and non-viral gene therapy partially prevents experimental cisplatin-induced neuropathy

    Sensory neuropathies are a frequent and dose-limiting complication resulting from treatment with cisplatin. Neurotrophin-3 (NT-3) promotes the survival of the large fiber sensory neurones that are impaired in ...

    P-F Pradat, P Kennel, S Naimi-Sadaoui, F Finiels, D Scherman, C Orsini… in Gene Therapy (2002)

  7. No Access

    Article

    Efficient gene transfer and long-term expression in neurons using a recombinant adenovirus with a neuron-specific promoter

    Adenoviruses are highly efficient vectors for gene transfer into brain cells. Restricting transgene expression to specific cell types and maintaining long-term expression are major goals for gene therapy in th...

    V Navarro, S Millecamps, M-C Geoffroy, J-J Robert, A Valin, J Mallet… in Gene Therapy (1999)

  8. No Access

    Article

    Adenovirus-mediated transfer of a functional GAD gene into nerve cells: potential for the treatment of neurological diseases

    The recent development of efficient virus-mediated gene transfer into nerve cells allows the prospect of new strategies for the treatment of drug-resistant neurological diseases. Some forms of epilepsy may be ...

    JJ Robert, V Bouilleret, V Ridoux, A Valin, MC Geoffroy, J Mallet… in Gene Therapy (1997)

  9. No Access

    Chapter and Conference Paper

    Studies of the Neurotransmitter Plasticity of Cultured Rat Sympathetic Neurons at the Molecular Level

    Cultures of sympathetic neurons from new-born rats constitute an attractive model to study the triggering and modulation of the expression of neurotransmitter phenotypic traits during neuronal differentiation....

    M. J. Weber, B. Raynaud, S. Vidal, N. Faucon-Biguet… in Neural Development and Regeneration (1988)