8 Result(s)

Article

Osimertinib and anti-HER3 combination therapy engages immune dependent tumor toxicity via STING activation in trans

Over the past decade, immunotherapy delivered novel treatments for many cancer types. However, lung cancer still leads cancer mortality, and non-small-cell lung carcinoma patients with mutant EGFR cannot benef...

J. M. Vicencio, R. Evans, R. Green, Z. An, J. Deng, C. Treacy… in Cell Death & Disease (2022)

Article

Correction: Hearts deficient in both Mfn1 and Mfn2 are protected against acute myocardial infarction

A. R. Hall, N. Burke, R. K. Dongworth, S. B. Kalkhoran, A. Dyson… in Cell Death & Disease (2021)

Article

Hearts deficient in both Mfn1 and Mfn2 are protected against acute myocardial infarction

Mitochondria alter their shape by undergoing cycles of fusion and fission. Changes in mitochondrial morphology impact on the cellular response to stress, and their interactions with other organelles such as th...

A R Hall, N Burke, R K Dongworth, S B Kalkhoran, A Dyson… in Cell Death & Disease (2016)

Article

A brain-specific isoform of mitochondrial apoptosis-inducing factor: AIF2

Apoptosis-inducing factor (AIF) has important supportive as well as potentially lethal roles in neurons. Under normal physiological conditions, AIF is a vital redox-active mitochondrial enzyme, whereas in path...

E Hangen, D De Zio, M Bordi, C Zhu, P Dessen, F Caffin… in Cell Death & Differentiation (2010)

Article

The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1

The inositol 1,4,5-trisphosphate receptor (IP₃R) is a major regulator of apoptotic signaling. Through interactions with members of the Bcl-2 family of proteins, it drives calcium (Ca²⁺) transients from the endopl...

J M Vicencio, C Ortiz, A Criollo, A W E Jones, O Kepp… in Cell Death & Differentiation (2009)

Article

Autophagy within the antigen donor cell facilitates efficient antigen cross-priming of virus-specific CD8⁺ T cells

Cross-presentation of cell-associated antigen is important in the priming of CD8⁺ T-cell responses to proteins that are not expressed by antigen-presenting cells (APCs). In vivo, dendritic cells are the main cros...

M Uhl, O Kepp, H Jusforgues-Saklani, J-M Vicencio… in Cell Death & Differentiation (2009)

Article

Control of autophagy by oncogenes and tumor suppressor genes

Multiple oncogenes (in particular phosphatidylinositol 3-kinase, PI3K; activated Akt1; antiapoptotic proteins from the Bcl-2 family) inhibit autophagy. Similarly, several tumor suppressor proteins (such as BH3...

M C Maiuri, E Tasdemir, A Criollo, E Morselli, J M Vicencio… in Cell Death & Differentiation (2009)