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Article
The role of mammalian antimicrobial peptides and proteins in awakening of innate host defenses and adaptive immunity
Since we live in a dirty environment, we have developed many host defenses to contend with microorganisms. The epithelial lining of our skin, gastrointestinal tract and bronchial tree produces a number of anti...
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Article
Characterization of chenodeoxycholic acid as an endogenous antagonist of the G-coupled formyl peptide receptors
Objective and design: To demonstrate the role of bile acids in immune modulation we examined the ability of select bile acids to inhibit leukocyte migration and chemoattractant receptor ...
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Article
Chemokines, receptors, and their role in cardiovascular pathology
A superfamily of leukocyte chemotactic proteins, known as chemokines, has been identified during the past decade. Chemokines selectively attract and activate different leukocyte subpopulations and are key medi...
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Chapter
Promiscuity Of Ligand Binding In The Chemokine Beta Receptor Family
Ligand receptor interactions by chemokine beta cytokines stimulate a variety of cellular and subcellular events including monocyte and T-cell chemotaxis, adhesion, calcium mobilization and histamine release. T...
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Chapter
Cytokines Interaction in Innate and Immunomodulator-Induced Radioprotection
Ionizing radiation is particularly damaging to lymphoid and hematopoietic tissues, leading to anemia and decreased resistance to opportunistic infections, often resulting in death (1). Enhancing host defenses ...
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Chapter and Conference Paper
The Cytokine Network: Contributions of Proinflammatory Cytokines and Chemokines
Cytokines were initially detected beginning in 1964 as biologically active factors that appeared in supernatants of stimulated leucocyte cultures. During the past decade advances in molecular biology and bioch...
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Chapter
Properties and binding characteristics of monocyte chemotactic and activating factor (MCAF)
The directional migration and accumulation of monocytes at inflammatory sites is mediated by a variety of cell-derived mediators and bacterial peptides (1). Monocyte chemotactic and activating factor (MCAF), w...
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Article
Relationship between interleukin 1 (IL1), tumor necrosis factor (TNF) and a neutrophil attracting peptide (NAP-1)
Although IL 1 and TNF are biochemically distinct and bind to different cell membrane receptors, they each exhibit only a few distinct biological properties, and have a great number of activities in common. Thu...
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Chapter
Possible Autoregulatory Roles of Interleukin 1 for Normal Human Epithelial Cells, Monocytes and B Lymphocytes
Of all the hormones and growth factors that have been tested only interleukin 1 and 2 (IL 1 and 2) have been documented to be costimulants of thymocyte proliferation. Consequently the operational definition of...
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Chapter
Autoregulatory effects of interleukin 1 on human monocytes
Interleukin 1 (IL 1) is a cytokine which was initially defined as an immunologically nonspecific monocyte/ macrophage-derived factor that enhances the proliferative response of murine thymocytes (1). In this a...
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Chapter
Bi-Directional Macrophage-Lymphocyte Interactions Modulate Immune Responses
The activation of macrophages and lymphocytes is initiated by exogenous stimuli which often are bacterial in origin. Some of the most potent activating agents are bacterial endotoxin lipopoly- saccharide (LPS)...
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Article
Induction of lymphokine production by EAC and of blastogenesis by soluble mitogens during human B-cell activation
Two groups of human lymphocytes are distinguished on the basis of immune effector functions, membrane markers and in vitro mitogen reactivity. Thymus-derived (T) lymphocytes mediate cellular immunity either direc...
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Chapter
Contribution of B and T Lymphocytes to in Vitro Chicken Proliferative Spleen Cell Reactions to Antigens
Antigen stimulated cultures of spleen cells from normal chickens immunized with Keyhole Limpet Hemocyanin (KLH) and Brucella abortus antigen (BA) show significantly increased proliferative responses in comparison...
