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Article
Open AccessReverse re-modelling chronic heart failure by reinstating heart rate variability
Heart rate variability (HRV) is a crucial indicator of cardiovascular health. Low HRV is correlated with disease severity and mortality in heart failure. Heart rate increases and decreases with each breath in ...
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Article
Electrocardiographic detection of hypertensive left atrial enlargement in the presence of obesity: re-calibration against cardiac magnetic resonance
Left atrial enlargement (LAE) has adverse prognostic implications in hypertension. We sought to determine the accuracy of five electrocardiogram (ECG) criteria for LAE in hypertension relative to cardiac magne...
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Article
Open AccessThe effect of obesity on electrocardiographic detection of hypertensive left ventricular hypertrophy: recalibration against cardiac magnetic resonance
Electrocardiograph (ECG) criteria for left ventricular hypertrophy (LVH) are a widely used clinical tool. We recalibrated six ECG criteria for LVH against gold-standard cardiac magnetic resonance (CMR) and ass...
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Article
Correction: Corrigendum: Lactate-mediated glia-neuronal signalling in the mammalian brain
Nature Communications 5: Article number: 3284 (2014); Published: 11 February 2014; Updated: 28 May 2014. While this Article was under consideration, Bozzo et al. published their findings on the inhibitory effe...
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Article
Open AccessLactate-mediated glia-neuronal signalling in the mammalian brain
Astrocytes produce and release L-lactate as a potential source of energy for neurons. Here we present evidence that L-lactate, independently of its caloric value, serves as an astrocytic signalling molecule in th...
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Article
The sympathetic nervous system and blood pressure in humans: implications for hypertension
A neurogenic component to primary hypertension (hypertension) is now well established. Along with raised vasomotor tone and increased cardiac output, the chronic activation of the sympathetic nervous system in...
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Article
Reorganisation of respiratory network activity after loss of glycinergic inhibition
γ-Aminobutyric acid (GABA)-ergic and glycinergic inhibition is believed to play a major role in the respiratory network. In the present study we tested whether specific blockade of glycinergic inhibition resu...
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Article
Influence of the cerebellar posterior vermis on the acquisition of the classically conditioned bradycardic response in the rabbit
The magnitude of classically conditioned bradycardia was studied in rabbits in which various cerebellar regions (lobule IX or the posterior vermis or the hemispheres) had been removed surgically. Lesions were ...
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Chapter
The Central Nervous Organization of the Carotid Body Chemoreceptor Reflex
There is both anatomical and neurophysiological evidence to indicate that the primary synapses in the arterial chemoreceptor reflex are located within the nucleus tractus solitarius (NTS). Indeed, it appears t...
