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Chapter
Topology Optimization in Linear Elasticity, Plasticity and Fracture Mechanics
This chapter presents the theoretical and the numerical study of shape and topology optimization for linear elasticity, plasticity and fracture using the level-set method. The governing equation of linear elas...
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Article
Do most premature babies get discharged by the expected date of delivery?
To compare the length of stay (LOS) against the expected date of delivery (EDD) and to describe mortality and LOS outcomes by gestational age (GA) categories over the years.
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Article
Open AccessLong-term efficacy of imatinib mesylate in patients with advanced Tenosynovial Giant Cell Tumor
Tenosynovial giant cell tumors (TGCT), are rare colony stimulating factor-1(CSF-1)-driven proliferative disorders affecting joints. Diffuse-type TGCT often causes significant morbidity due to local recurrences...
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Article
Gender differences in doxorubicin pharmacology for subjects with chemosensitive cancers of young adulthood
For many cancers, adolescents and young adults (AYA) have worse outcomes than for children and adults. Many factors may contribute to the AYA survival gap, including differences in biology, therapeutic intent,...
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Article
Open AccessA phase Ib/II translational study of sunitinib with neoadjuvant radiotherapy in soft-tissue sarcoma
Preoperative radiotherapy (RT) is commonly used to treat localised soft-tissue sarcomas (STS). Hypoxia is an important determinant of radioresistance. Whether antiangiogenic therapy can ‘normalise’ tumour vasc...
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Article
Open AccessDifferent APC genotypes in proximal and distal sporadic colorectal cancers suggest distinct WNT/β-catenin signalling thresholds for tumourigenesis
Biallelic protein-truncating mutations in the adenomatous polyposis coli (APC) gene are prevalent in sporadic colorectal cancer (CRC). Mutations may not be fully inactivating, instead producing WNT/β-catenin sign...
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Article
Neurofibromatosis type 1-associated wild-type gastrointestinal stromal tumor treated with anti-IGF-1R monoclonal antibody
Gastrointestinal stromal tumors lacking mutations in KIT or PDGFRα are known as wild type (WT) and are less responsive to imatinib. These WT tumors are hypothesized to be dependent on signaling through the insuli...
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Chapter and Conference Paper
Quantitative Characterization of Radiofrequency Ablation Lesions in Tissue Using Optical Coherence Tomography
Radiofrequency (RF) ablation is a widely used therapeutic intervention in the management of many cancers including breast and liver cancers. While optimum delivery of RF energy can be monitored through real-ti...
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Article
Safe administration of etoposide phosphate after hypersensitivity reaction to intravenous etoposide
Etoposide is commonly used in a variety of malignancies. A well known but rare toxicity are hypersensitivity reactions, usually manifested by chest discomfort, dyspnoea, bronchospasm and hypotension. We report...
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Article
Irish cardiac society
