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Article
Experimental analysis and FLUENT simulation of a stratified chilled water storage system
The purpose of this study is to figure out the hydrodynamic disturbance characteristics and chilled water storage efficiency improvement technique of a storage tank by a series of experimental analysis and FLU...
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Article
Diagnostic criteria for diabetes in China: are we pushing too much beyond evidence?
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Article
Open AccessClinico-biological significance of suppressor of cytokine signaling 1 expression in acute myeloid leukemia
Suppressor of cytokine signaling 1 (SOCS1) protein, which encodes a member of signal transducers and activators of transcription-induced inhibitors, takes part in a negative regulation of cytokine signaling. T...
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Article
Open AccessIdeal cardiovascular health status and its association with socioeconomic factors in Chinese adults in Shandong, China
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the world. In 2010, a goal released by the American Heart Association (AHA) Committee focused on the primary reduction in cardiov...
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Article
Genetic alterations and their clinical implications in older patients with acute myeloid leukemia
A number of patient-specific and leukemia-associated factors are related to the poor outcome in older patients with acute myeloid leukemia (AML). However, comprehensive studies regarding the impact of genetic ...
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Article
Open AccessTP53 mutations in de novo acute myeloid leukemia patients: longitudinal follow-ups show the mutation is stable during disease evolution
The TP53 mutation is frequently detected in acute myeloid leukemia (AML) patients with complex karyotype (CK), but the stability of this mutation during the clinical course remains unclear. In this study, TP53 mu...
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Article
Open AccessDynamics of ASXL1 mutation and other associated genetic alterations during disease progression in patients with primary myelodysplastic syndrome
Recently, mutations of the additional sex comb-like 1 (ASXL1) gene were identified in patients with myelodysplastic syndrome (MDS), but the interaction of this mutation with other genetic alterations and its dyna...
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Article
Integration of cytogenetic and molecular alterations in risk stratification of 318 patients with de novo non-M3 acute myeloid leukemia
Conventionally, acute myeloid leukemia (AML) patients are categorized into good-, intermediate- and poor-risk groups according to cytogenetic changes. However, patients with intermediate-risk cytogenetics repr...
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Article
Modeling and Predicting the Central Magnetic Flux Density of the Superconducting Solenoid Surrounded with Iron Yoke via SVR
A novel machine learning method based on support vector regression (SVR) approach, combined with a particle swarm optimization (PSO) algorithm for its parameter optimization, was proposed to predict the magnet...
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Article
Mycobacterial infections in adult patients with hematological malignancy
We retrospectively analyzed the clinical and microbiological characteristics of adult patients with hematological malignancy and nontuberculous mycobacteria (NTM) infections from 2001 to 2010. During the study...
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Article
Open AccessDistinct association between aberrant methylation of Wnt inhibitors and genetic alterations in acute myeloid leukaemia
Aberrant activation of Wnt signalling through hypermethylation of Wnt inhibitor genes is involved in several human malignancies, including acute myeloid leukaemia (AML). It remains unclear whether hypermethyla...
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Article
Open AccessHigh bone marrow angiopoietin-1 expression is an independent poor prognostic factor for survival in patients with myelodysplastic syndromes
Angiogenic factors have an essential role in normal and pathologic angiogenesis. However, the clinical implication of angiogenic factor expression in myelodysplastic syndromes (MDS) remains unclear.
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Article
The prognostic impact and stability of Isocitrate dehydrogenase 2 mutation in adult patients with acute myeloid leukemia
Although the clinical features of the Isocitrate dehydrogenase 2 (IDH2) mutation in acute myeloid leukemia (AML) have been characterized, its prognostic significance remains controversial and its stability has no...
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Article
Acute myeloid leukemia bearing t(7;11)(p15;p15) is a distinct cytogenetic entity with poor outcome and a distinct mutation profile: comparative analysis of 493 adult patients
Acute myeloid leukemia (AML) with t(7;11)(p15;p15), which results in a NUP98–HOXA9 fusion, is a distinct entity, but this subtype has not been characterized in detail. In a comprehensive study comparing 11 such p...
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Article
Poor outcome in post transplant lymphoproliferative disorder with pulmonary involvement after allogeneic hematopoietic SCT: 13 years' experience in a single institute
EBV-induced post transplant lymphoproliferative disorder (PTLD) continues to be a major complication after transplantation. Between January 1993 and April 2006, 12 cases of B-cell lymphoproliferative disorder ...
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Article
Efficacy and safety of dasatinib in imatinib-resistant or -intolerant patients with chronic myeloid leukemia in blast phase
Dasatinib is an inhibitor of BCR-ABL and SRC-family kinases for patients with imatinib-resistant or -intolerant chronic myelogenous leukemia (CML). In this international phase II trial, dasatinib was administe...
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Article
Characterization of acute myeloid leukemia with PTPN11 mutation: the mutation is closely associated with NPM1 mutation but inversely related to FLT3/ITD
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Article
Open AccessHigh tunabilty Ba0.6Sr0.4TiO3 thin films fabricated on Pt–Si substrates with La0.5Sr0.5CoO3 buffer layer
Ba0.6Sr0.4TiO3 (BST) thin films for the tunable microwave devices were grown using pulsed laser deposition (PLD) on Pt/Ti/SiO2/Si (Pt–Si) substrates with La0.5Sr0.5CoO3 (LSCO) buffer layers. For comparison, the f...
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Article
Comparison of hypoplastic myelodysplastic syndrome (MDS) with normo-/hypercellular MDS by International Prognostic Scoring System, cytogenetic and genetic studies
The differences in clinical features and prognosis between hypoplastic myelodysplastic syndrome (h-MDS) and normo-/hypercellular MDS (NH-MDS) remain unsettled. In this study, the characteristics of 37 h-MDS pa...
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Article
Enhanced electrical properties of multilayer Ba(Zr0.2Ti0.8)O3/Ba0.6Sr0.4TiO3/Ba(Zr0.2Ti0.8)O3thin films for tunable microwave applications