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  1. No Access

    Article

    A novel 3p22.3 gene CMTM7 represses oncogenic EGFR signaling and inhibits cancer cell growth

    Deletion of 3p12-22 is frequent in multiple cancer types, indicating the presence of critical tumor-suppressor genes (TSGs) at this region. We studied a novel candidate TSG, CMTM7, located at the 3p22.3 CMTM-gene...

    H Li, J Li, Y Su, Y Fan, X Guo, L Li, X Su, R Rong, J Ying, X Mo, K Liu… in Oncogene (2014)

  2. Article

    Open Access

    The human cadherin 11 is a pro-apoptotic tumor suppressor modulating cell stemness through Wnt/β-catenin signaling and silenced in common carcinomas

    Genetic alterations of 16q21-q22, the locus of a 6-cadherin cluster, are frequently involved in multiple tumors, suggesting the presence of critical tumor suppressor genes (TSGs). Using 1 Mb array comparative ...

    L Li, J Ying, H Li, Y Zhang, X Shu, Y Fan, J Tan, Y Cao, S W Tsao, G Srivastava… in Oncogene (2012)

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  3. Article

    Erratum: Epigenetic inactivation of paired box gene 5, a novel tumor suppressor gene, through direct upregulation of p53 is associated with prognosis in gastric cancer patients

    Correction to: Oncogene (2012) 31, 3419–3430; published online 21 November 2011; doi:10.1038/onc.2011.511 Since the publication of the above manuscript, the authors have identified an error; the PAX5 gene is l...

    X Li, K F Cheung, X Ma, L Tian, J Zhao, M Y Y Go, B Shen, A S L Cheng, J Ying… in Oncogene (2012)

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  4. No Access

    Article

    Epigenetic inactivation of paired box gene 5, a novel tumor suppressor gene, through direct upregulation of p53 is associated with prognosis in gastric cancer patients

    Using genome-wide methylation screening, we identified that paired box gene 5 (PAX5) is involved in human cancer development. However, the function of PAX5 in gastric cancer (GC) development is largely unclear. W...

    X Li, K F Cheung, X Ma, L Tian, J Zhao, M Y Y Go, B Shen, A S L Cheng, J Ying… in Oncogene (2012)

  5. No Access

    Article

    Epigenetic disruption of interferon-γ response through silencing the tumor suppressor interferon regulatory factor 8 in nasopharyngeal, esophageal and multiple other carcinomas

    16q24 is frequently deleted in multiple tumors including cancers of nasopharynx, esophagus, breast, prostate and liver. By array comparative genomic hybridization (aCGH), we refined a 16q24 hemizygous deletion...

    K Y Lee, H Geng, K M Ng, J Yu, A van Hasselt, Y Cao, Y-X Zeng, A H Y Wong… in Oncogene (2008)

  6. No Access

    Article

    Epigenetic identification of ADAMTS18 as a novel 16q23.1 tumor suppressor frequently silenced in esophageal, nasopharyngeal and multiple other carcinomas

    Tumor suppressor genes (TSGs) often locate at chromosomal regions with frequent deletions in tumors. Loss of 16q23 occurs frequently in multiple tumors, indicating the presence of critical TSGs at this locus, ...

    H **, X Wang, J Ying, A H Y Wong, H Li, K Y Lee, G Srivastava, A T C Chan… in Oncogene (2007)

  7. No Access

    Article

    Identification of a novel tumor transforming gene GAEC1 at 7q22 which encodes a nuclear protein and is frequently amplified and overexpressed in esophageal squamous cell carcinoma

    By comparative DNA fingerprinting, we identified a 357-bp DNA fragment frequently amplified in esophageal squamous cell carcinomas (ESCC). This fragment overlaps with an expressed sequence tag mapped to 7q22. ...

    F B F Law, Y W Chen, K Y Wong, J Ying, Q Tao, C Langford, P Y Lee, S Law… in Oncogene (2007)

  8. No Access

    Article

    Functional epigenetics identifies a protocadherin PCDH10 as a candidate tumor suppressor for nasopharyngeal, esophageal and multiple other carcinomas with frequent methylation

    Protocadherins constitute the largest subgroup in the cadherin superfamily of cell adhesion molecules. Their major functions are poorly understood, although some are implicated in nervous system development. A...

    J Ying, H Li, T J Seng, C Langford, G Srivastava, S W Tsao, T Putti, P Murray… in Oncogene (2006)