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Article

Association between cyclo-oxygenase-2 overexpression and missense p53 mutations in gastric cancer

Wild-type p53 competitively binds to the promoter region of COX-2 in vitro and inhibits its transcription. We examined the association between p53 mutation and COX-2 expression in gastric cancer. COX-2 over-expre...

W K Leung, K-F To, Y-P Ng, T-L Lee, J Y W Lau, F K L Chan… in British Journal of Cancer (2001)