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Article
Classifying the adverse mitogenic mode of action of insulin analogues using a novel mechanism-based genetically engineered human breast cancer cell panel
Insulin analogues are widely used in clinical practice. Modifications on the insulin molecular structure can affect the affinity and activation towards two closely related receptor tyrosine kinases: the insuli...
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Article
The value of non-human primates in the development of monoclonal antibodies
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Article
Chronic infusion of clonidine does not alleviate spontaneous morphine withdrawal symptoms in rats
Opiate withdrawal is associated with behavioural symptoms and a sympathetic hyperactivity, the latter being sensitive to clonidine. The central question is whether behavioural symptoms would be also sensitive ...
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Article
Dipropylacetate-induced quasi-morphine abstinence behaviour in the rat: Suppression by a 2-adrenoceptor stimulation
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Article
Dipropylacetate-induced quasi-morphine abstinence behaviour in the rat: Suppression by α2-Adrenoceptor stimulation
The anti-withdrawal effect of clonidine was studied using quasi-morphine abstinence behaviour induced by dipropylacetate (DPA) in naive rats. Clonidine potently suppressed body shakes and locomotor activity (ID50
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Article
A dual role for GABA in quasi-morphine abstinence behavior induced by di-n-propylacetate involving both initiation and termination
Di-n-propylacetate (DPA) induces a behavioral syndrome in rats resembling morphine abstinence behavior. The inhibitory action of DPA on GABA degradation, resulting in an enhanced release of GABA, is probably r...