41 Result(s)

Article

Determinanten gesundheitsbezogener Lebensqualität bei systemischem Lupus erythematodes: eine monozentrische, retrospektive Langzeitobservationsstudie in Deutschland

Die Verbesserung der gesundheitsbezogenen Lebensqualität (HRQoL) ist ein übergeordnetes Behandlungsziel beim systemischen Lupus erythematodes (SLE). Patientendaten mit wiederholten HRQoL-Messungen aus unserer ...

PD Dr. S. Vordenbäumen, R. Brinks, O. Sander, G. Chehab… in Zeitschrift für Rheumatologie (2019)

Article

Differences between BCL2-break positive and negative follicular lymphoma unraveled by whole-exome sequencing

Depending on disease stage follicular lymphoma (FL) lack the t(14;18) in ~15–~50% of cases. Nevertheless, most of these cases express BCL2. To elucidate mechanisms triggering BCL2 expression and promoting path...

A Zamò, J Pischimarov, M Schlesner, P Rosenstiel, R Bomben, H Horn, T Grieb… in Leukemia (2018)

Article

Safety and efficacy of the combination of pegylated interferon-α2b and dasatinib in newly diagnosed chronic-phase chronic myeloid leukemia patients

Dasatinib (DAS) and interferon-α have antileukemic and immunostimulatory effects and induce deep responses in chronic myeloid leukemia (CML). We assigned 40 newly diagnosed chronic-phase CML patients to receiv...

H Hjorth-Hansen, J Stentoft, J Richter, P Koskenvesa, M Höglund, A Dreimane… in Leukemia (2016)

Article

Increased prevalence of prior malignancies and autoimmune diseases in patients diagnosed with chronic myeloid leukemia

We recently reported an increased incidence of second malignancies in chronic myeloid leukemia (CML) patients treated with tyrosine kinase inhibitors (TKI). To elucidate whether this increase may be linked, no...

N Gunnarsson, M Höglund, L Stenke, S Wållberg-Jonsson, F Sandin, M Björkholm… in Leukemia (2016)

Article

IL1RAP expression as a measure of leukemic stem cell burden at diagnosis of chronic myeloid leukemia predicts therapy outcome

N Landberg, N Hansen, M Askmyr, H Ågerstam, C Lassen, M Rissler… in Leukemia (2016)

Article

Analysis of mutational signatures in exomes from B-cell lymphoma cell lines suggest APOBEC3 family members to be involved in the pathogenesis of primary effusion lymphoma

R Wagener, L B Alexandrov, M Montesinos-Rongen, M Schlesner, A Haake… in Leukemia (2015)

Article

The mutational pattern of primary lymphoma of the central nervous system determined by whole-exome sequencing

To decipher the mutational pattern of primary CNS lymphoma (PCNSL), we performed whole-exome sequencing to a median coverage of 103 × followed by mutation verification in 9 PCNSL and validation using Sanger se...

I Vater, M Montesinos-Rongen, M Schlesner, A Haake, F Purschke, R Sprute… in Leukemia (2015)

Article

A B-cell epigenetic signature defines three biologic subgroups of chronic lymphocytic leukemia with clinical impact

Prospective identification of patients with chronic lymphocytic leukemia (CLL) destined to progress would greatly facilitate their clinical management. Recently, whole-genome DNA methylation analyses identifie...

A C Queirós, N Villamor, G Clot, A Martinez-Trillos, M Kulis, A Navarro… in Leukemia (2015)

Article

Placental Schistosoma haematobium infection in a German returnee from Malawi

Schistosomiasis is a widespread helminthic infection which sometimes may affect travelers to endemic areas. We report on a case of urogenital and placental schistosomiasis in a 28-year-old German woman who had...

B. T. Schleenvoigt, M. Gajda, M. Baier, T. Groten, H. Oppel-Heuchel… in Infection (2014)

Article

Möglichkeiten und Grenzen patientenberichteter Endpunkte am Beispiel des systemischen Lupus erythematodes und der LuLa-Studie

Patientenberichtete Endpunkte bzw. „patient-reported outcomes“ (PRO) haben in den letzten drei Jahrzehnten eine zunehmende Bedeutung in der Beurteilung von Krankheitsverläufen und Therapieansprechen erfahren. ...

Dr. G. Chehab, J. Richter, M. Schneider in Zeitschrift für Rheumatologie (2014)

Article

55-jährige Patientin mit Husten, Fieber, Gelenkschwellungen und Exanthem nach einem Urlaub in Ecuador

Eine 55-jährige Patientin stellte sich 16 Monate nach Aufenthalt in Ecuador mit einem unklaren Lungenbefund vor. Es bestanden Nachtschweiß und allgemeine Schwäche. In der Computertomographie zeigte sich ein 14...

Dr. I. Müller-Stöver, K. Tintelnot, J. Richter, D. Häussinger in Der Internist (2014)

Article

RNA-seq identifies clinically relevant fusion genes in leukemia including a novel MEF2D/CSF1R fusion responsive to imatinib

H Lilljebjörn, H Ågerstam, C Orsmark-Pietras, M Rissler, H Ehrencrona… in Leukemia (2014)