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  1. No Access

    Article

    A functional C–G polymorphism in the CYP7B1 promoter region and its different distribution in Orientals and Caucasians

    Cytochrome P450 (CYP) 7B1 is involved in many metabolic processes including androgen metabolism. Genetic variation in the CYP7B1 gene may play a role in predisposition to prostate cancer. Here, we screened the hu...

    J Jakobsson, H Karypidis, J-E Johansson, H-K Roh, A Rane… in The Pharmacogenomics Journal (2004)

  2. No Access

    Article

    Efficient transduction of neurons using Ross River glycoprotein-pseudotyped lentiviral vectors

    Lentiviral vectors are promising tools for CNS gene transfer since they efficiently transduce the cells of the nervous system in vivo. In this study, we have investigated the transduction efficiency of lentiviral...

    J Jakobsson, T Tolstrup Nielsen, K Staflin, B Georgievska, C Lundberg in Gene Therapy (2006)

  3. No Access

    Article

    A novel polymorphism in the 17β-hydroxysteroid dehydrogenase type 5 (aldo-keto reductase 1C3) gene is associated with lower serum testosterone levels in caucasian men

    Genetic variation in the androgen metabolizing enzymes is important to identify and feature as they may influence the risk of prostate cancer and help clarify the etiology of the disease. Human 17β-hydroxysteroid...

    J Jakobsson, E Palonek, M Lorentzon, C Ohlsson, A Rane… in The Pharmacogenomics Journal (2007)