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Article
Action of Nitrogen Trichloride on Proteins : Production of Toxic Derivative
FOLLOWING Mellanby‘s discovery1 that ‘‘Agenized wheaten flour, when fed to dogs, produces hysteria, it was shown in a first paper2 from these laboratories that the syndrome is not due to a nutritional deficiency ...
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Article
Toxic Effect of the Crystals from ‘Agenized’ Zein on Certain Acid-producing Bacteria
THE crystalline material described above has been tested against several organisms used chiefly for microbiological assay. These tests have shown that the crystals are markedly toxic to the organism Leuconostoc m...
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Article
Inhibition of the Growth of Leuconostoc mesenteroides by the Toxic Factor from ‘Agenized’ Zein: Reversal by L-Glutamine
THE crystalline toxic factor originally isolated1 from zein treated with nitrogen trichloride causes epileptiform fits in certain animals and inhibits the growth of Leuconostoc mesenteroides P-602. The subsequent...
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Article
Oral Treatment of Pernicious Anæmia with a Vitamin B12/L~Glutamic Acid Mixture
ACCORDING to Castle1, pernicious anæmia is due to failure of the stomach to secrete a high-molecular-weight, non-dialysable protein (intrinsic factor) which facilitates the absorption of pure vitamin B12 (extrins...
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Article
Absorption of Vitamin B12-Glutamic Acid Mixture
THE authors of the preceding communication state that “According to them [Heathcote and Mooney], vitamin B12 is absorbed as either small peptide or amino-acid units”. We trust that this misinterpretation of our a...
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Article
Oral Treatment of Pernicious Anaemia
IT will not surprise many workers in the B12 field to read that Dr. Heinivaara and Dr. Palva have obtained a remission over a period of 50 days in one case of pernicious anaemia, which was receiving a daily dosag...