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Article
DIXDC1 contributes to psychiatric susceptibility by regulating dendritic spine and glutamatergic synapse density via GSK3 and Wnt/β-catenin signaling
Mice lacking DIX domain containing-1 (DIXDC1), an intracellular Wnt/β-catenin signal pathway protein, have abnormal measures of anxiety, depression and social behavior. Pyramidal neurons in these animals’ brai...
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Article
Open AccessGenome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia
Borderline personality disorder (BOR) is determined by environmental and genetic factors, and characterized by affective instability and impulsivity, diagnostic symptoms also observed in manic phases of bipola...
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Article
Open AccessGenetic effects influencing risk for major depressive disorder in China and Europe
Major depressive disorder (MDD) is a common, complex psychiatric disorder and a leading cause of disability worldwide. Despite twin studies indicating its modest heritability (~30–40%), extensive heterogeneity...
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Article
High-throughput sequencing of the synaptome in major depressive disorder
Major depressive disorder (MDD) is among the leading causes of worldwide disability. Despite its significant heritability, large-scale genome-wide association studies (GWASs) of MDD have yet to identify robust...
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Article
Open AccessSearch for common targets of lithium and valproic acid identifies novel epigenetic effects of lithium on the rat leptin receptor gene
Epigenetics may have an important role in mood stabilizer action. Valproic acid (VPA) is a histone deacetylase inhibitor, and lithium (Li) may have downstream epigenetic actions. To identify genes commonly aff...
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Article
The association between lower educational attainment and depression owing to shared genetic effects? Results in ~25 000 subjects
An association between lower educational attainment (EA) and an increased risk for depression has been confirmed in various western countries. This study examines whether pleiotropic genetic effects contribute...
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Article
Open AccessType I interferon signaling genes in recurrent major depression: increased expression detected by whole-blood RNA sequencing
A study of genome-wide gene expression in major depressive disorder (MDD) was undertaken in a large population-based sample to determine whether altered expression levels of genes and pathways could provide in...
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Article
Metamoodics: meta-analysis and bioinformatics resource for mood disorders
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Article
Enrichment of cis-regulatory gene expression SNPs and methylation quantitative trait loci among bipolar disorder susceptibility variants
We conducted a systematic study of top susceptibility variants from a genome-wide association (GWA) study of bipolar disorder to gain insight into the functional consequences of genetic variation influencing d...
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Article
Open AccessGenome-wide association of mood-incongruent psychotic bipolar disorder
Mood-incongruent psychotic features (MICP) are familial symptoms of bipolar disorder (BP) that also occur in schizophrenia (SZ), and may represent manifestations of shared etiology between the major psychoses....
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Article
Genome-wide linkage analysis of 972 bipolar pedigrees using single-nucleotide polymorphisms
Because of the high costs associated with ascertainment of families, most linkage studies of Bipolar I disorder (BPI) have used relatively small samples. Moreover, the genetic information content reported in m...
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Article
A genome-wide association study of attempted suicide
The heritable component to attempted and completed suicide is partly related to psychiatric disorders and also partly independent of them. Although attempted suicide linkage regions have been identified on 2p1...
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Article
Genome-wide association study of recurrent early-onset major depressive disorder
A genome-wide association study was carried out in 1020 case subjects with recurrent early-onset major depressive disorder (MDD) (onset before age 31) and 1636 control subjects screened to exclude lifetime MDD...
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Article
Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies
We report a genome-wide association study (GWAS) of major depressive disorder (MDD) in 1221 cases from the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study and 1636 screened controls. No geno...
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Article
Genome-wide association study of bipolar disorder in European American and African American individuals
To identify bipolar disorder (BD) genetic susceptibility factors, we conducted two genome-wide association (GWA) studies: one involving a sample of individuals of European ancestry (EA; n=1001 cases; n=1033 contr...
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Article
Singleton deletions throughout the genome increase risk of bipolar disorder
An overall burden of rare structural genomic variants has not been reported in bipolar disorder (BD), although there have been reports of cases with microduplication and microdeletion. Here, we present a genom...
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Article
Family-based association of FKBP5 in bipolar disorder
The FKBP5 gene product forms part of a complex with the glucocorticoid receptor and can modulate cortisol-binding affinity. Variations in the gene have been associated with increased recurrence of depression and ...
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Genome-wide linkage scan of 98 bipolar pedigrees and analysis of clinical covariates
Despite compelling evidence that genetic factors contribute to bipolar disorder (BP), attempts to identify susceptibility genes have met with limited success. This may be due to the genetic heterogeneity of th...
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Erratum: Findings in an independent sample support an association between bipolar affective disorder and the G72/G30 locus on chromosome 13q33
Correction to: Molecular Psychiatry (2004) 9, 87–92. doi: 10.1038/sj.mp.4001453 In Table 1, page 90, the first two cells contain incorrect characters. The SNP name should read rs2027446 and the chromosome posi...
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Article
Linkage of bipolar affective disorder on chromosome 8q24: follow-up and parametric analysis
Our group first reported a linkage finding for bipolar (BP) disorder on chromosome 8q24 in a study of 50 multiplex pedigrees, with an HLOD score reaching 2.39. Recently, Cichon et al reported an LOD score of 3.62...