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Article
Open AccessClinical Characteristics of Developmentally Delayed Children based on Interdisciplinary Evaluation
The aim of this study is to examine the clinical characteristics of children suspected to have neurodevelopmental disorders and to present features that could be helpful diagnostic clues at the clinical assess...
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Article
Open AccessBone marrow stromal cells show distinct gene expression patterns depending on symptomatically involved organs in multiple myeloma
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Article
Clinical features of intratarsal keratinous cysts
Intratarsal keratinous cysts (IKCs) have been frequently misdiagnosed as chalazia or epidermal cysts. We reviewed a series of cases of IKCs to identify clinical features that distinguish IKCs from other eyelid...
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Article
Modulating mammary tumor growth, metastasis and immunosuppression by siRNA-induced MIF reduction in tumor microenvironment
Macrophage migration inhibitory factor (MIF) has been identified as a major gene product upregulated in breast cancer cells–tissues upon the accumulation of macrophages. However, regulatory role of MIF in tumo...
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Article
Open AccessNeural stem cell transplantation at critical period improves learning and memory through restoring synaptic impairment in Alzheimer’s disease mouse model
Alzheimer’s disease (AD) is characterized by neuronal loss in several regions of the brain. Recent studies have suggested that stem cell transplantation could serve as a potential therapeutic strategy to halt ...
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Article
Matched-pair analysis to compare the outcomes of a second salvage auto-SCT to systemic chemotherapy alone in patients with multiple myeloma who relapsed after front-line auto-SCT
The aims of this study were to investigate the outcomes of second salvage auto-SCT and to identify the impacts of a second auto-SCT compared with systemic chemotherapy alone on disease outcome. Data from 48 pa...
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Article
Open AccessIdentification and characterization of seed-specific transcription factors regulating anthocyanin biosynthesis in black rice
Black rice is rich in anthocyanin and is expected to have more healthful dietary potential than white rice. We assessed expression of anthocyanin in black rice cultivars using a newly designed 135 K Oryza sativa ...
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Article
SP600125 suppresses Cdk1 and induces endoreplication directly from G2 phase, independent of JNK inhibition
Cell cycle controls ensure that DNA replication (S phase) follows mitosis resulting in two precise copies of the genome. A failure of the control mechanisms can result in multiple rounds of DNA replication wit...
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Article
Expression and Role of Interleukin-6 in Distraction Osteogenesis
Distraction osteogenesis is a special form of bone healing in which well-controlled distraction stresses and consequent tensile strains within callus tissue induce very efficient new bone formation. Proinflamm...
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Article
The prevalence and risk factors associated with isolated untreated systolic hypertension in Korea: The Korean National Health and Nutrition Survey 2001
Although isolated systolic hypertension (ISH) increases the risk of coronary heart disease and stroke, more than any other hypertension subtype, the prevalence and risk factors associated with ISH in the Korea...
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Article
Activation of NF-κB by HDAC inhibitor apicidin through Sp1-dependent de novo protein synthesis: its implication for resistance to apoptosis
Histone deacetylase (HDAC) inhibitors are promising anti-cancer drugs, but these exert differential responses depending on the cell types. Here, we demonstrate a new mechanism for activation of nuclear factor-...
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Article
A correlation between the level of phenolic compounds and the antioxidant capacity in cooked-with-rice and vegetable soybean (Glycine max L.) varieties
This study was undertaken to determine the content of phenolic compounds contained in embryo, cotyledon and seed coat of nine soybean (Glycine max L.) varieties. The 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radi...
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Article
Analysis of phenolic compounds and isoflavones in soybean seeds (Glycine max (L.) Merill) and sprouts grown under different conditions
Soybeans (Glycine max (L.) Merill) are popularly known as a healthy food in many Asian countries and are mostly consumed as soymilk, tofu, and fermented products such as miso, temph, and sufu. The objective of th...
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Chapter
EM Algorithm and Optimal Censoring Schemes for Progressively Type-II Censored Bivariate Normal Data
The EM algorithm is used to find the maximum likelihood estimates (MLEs) of the parameters of a bivariate normal distribution based on progressively Type-II right censored samples. The asymptotic variances and...
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Article
Pretransplant imatinib can improve the outcome of nonmyeloablative stem cell transplantation without increasing the morbidity in Philadelphia chromosome-positive chronic myeloid leukemia
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Article
Plasmacytoid dendritic cells promote the clonal expansion of T cells with a Th1/Tc1 phenotype
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Chapter
EM Algorithm for Type-II Right Censored Bivariate Normal Data
EM algorithm is used to find the maximum likelihood estimates based on Type-II right censored samples from a bivariate normal distribution. The asymptotic variances and covariances of the MLEs are derived, usi...
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Article
Simple bone cyst occurring in calvarium
¶A 60 year-old female presented with a non-specific headache that she had experienced for 4 years. A simple skull X-ray indicated a well-defined, lobulated and radiolucent lesion with a thin sclerotic rim invo...
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Article
Intraperitoneal gene delivery mediated by a novel cationic liposome in a peritoneal disseminated ovarian cancer model
We have previously synthesized a new cationic liposome that displays high efficiency and low toxicity, 3β[l-ornithinamide-carbamoyl] cholesterol (O-Chol), using solid-phase synthesis. In this study, O-Chol was...
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Article
Role of NAD(P)H oxidase in the tamoxifen-induced generation of reactive oxygen species and apoptosis in HepG2 human hepatoblastoma cells
Previously, tamoxifen (TAM) has been shown to induce apoptosis through elevation of intracellular Ca2+ in HepG2 human hepatoblastoma cells. In this study we investigated the role of reactive oxygen species (ROS) ...