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Macrolide Use in Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a progressive inflammatory airway disease characterized by non-reversible airflow limitation and chronic respiratory symptoms. Symptoms may periodically worsen d...
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Article
Open AccessPrincipal component analysis of flow-volume curves in COPDGene to link spirometry with phenotypes of COPD
Parameters from maximal expiratory flow-volume curves (MEFVC) have been linked to CT-based parameters of COPD. However, the association between MEFVC shape and phenotypes like emphysema, small airways disease ...
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Article
Open AccessCorrection to: Direct antivirals working against the novel coronavirus: azithromycin (DAWn-AZITHRO), a randomized, multicenter, open-label, adaptive, proof-of-concept clinical trial of new antivirals working against SARS-CoV-2—azithromycin trial
An amendment to this paper has been published and can be accessed via the original article.
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Article
Open AccessDirect antivirals working against the novel coronavirus: azithromycin (DAWn-AZITHRO), a randomized, multicenter, open-label, adaptive, proof-of-concept clinical trial of new antivirals working against SARS-CoV-2—azithromycin trial
The rapid emergence and the high disease burden of the novel coronavirus SARS-CoV-2 have created a medical need for readily available drugs that can decrease viral replication or blunt the hyperinflammatory st...
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Article
Open AccessTreatment failure and hospital readmissions in severe COPD exacerbations treated with azithromycin versus placebo – a post-hoc analysis of the BACE randomized controlled trial
In the BACE trial, a 3-month (3 m) intervention with azithromycin, initiated at the onset of an infectious COPD exacerbation requiring hospitalization, decreased the rate of a first treatment failure (TF); the...
