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Article
Open AccessmiR-218-5p and doxorubicin combination enhances anticancer activity in breast cancer cells through Parkin-dependent mitophagy inhibition
Breast Cancer (BC) is one of the most common tumours, and is known for its ability to develop resistance to chemotherapeutic treatments. Autophagy has been linked to chemotherapeutic response in several types ...
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Article
Open AccessAn ontology-based approach for modelling and querying Alzheimer’s disease data
The recent advances in biotechnology and computer science have led to an ever-increasing availability of public biomedical data distributed in large databases worldwide. However, these data collections are far...
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Article
Gene Expression Profiling as a New Real-Time Assay in Human Biomonitoring of Waste-to-Energy Plant Workers
Exposure to heavy metals represents one of the most important risk factors for the health of incinerator workers. Indeed, heavy metals can determine increased generation of reactive oxygen species (ROS). In th...
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Article
Open AccessBiomarkers and phenotypic expression in Alzheimer’s disease: exploring the contribution of frailty in the Alzheimer’s Disease Neuroimaging Initiative
The present study aimed at investigating if the main biomarkers of Alzheimer’s disease (AD) neuropathology and their association with cognitive disturbances and dementia are modified by the individual’s frailt...
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Article
Open AccessGenomic and physiological resilience in extreme environments are associated with a secure attachment style
Understanding individual capability to adjust to protracted confinement and isolation may inform adaptive plasticity and disease vulnerability/resilience, and may have long-term implications for operations req...
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Article
Timp3 deficiency affects the progression of DEN-related hepatocellular carcinoma during diet-induced obesity in mice
Obesity and low-grade inflammation are associated with an increased risk of hepatocellular carcinoma (HCC), a leading cause of cancer-related death worldwide. The tissue inhibitor of metalloproteinase (TIMP) 3...
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Article
Open AccessCorrection to: A miRNA catalogue and ncRNA annotation of the short-living fish Nothobranchius furzeri
Following the publication of this article [1], the authors reported that the images of Figs. 1, 2 and 3 were published in the incorrect order, whereby they mismatch with their captions.
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Article
Open AccessA miRNA catalogue and ncRNA annotation of the short-living fish Nothobranchius furzeri
The short-lived fish Nothobranchius furzeri is the shortest-lived vertebrate that can be cultured in captivity and was recently established as a model organism for aging research. Small non-coding RNAs, especiall...
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Article
Lamin A/C Is Required for ChAT-Dependent Neuroblastoma Differentiation
The mouse neuroblastoma N18TG2 clone is unable to differentiate and is defective for the enzymes of the biosynthesis of neurotransmitters. The forced expression of choline acetyltransferase (ChAT) in these cel...
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Article
Open AccessMDM4 actively restrains cytoplasmic mTORC1 by sensing nutrient availability
Many tumor-related factors have shown the ability to affect metabolic pathways by paving the way for cancer-specific metabolic features. Here, we investigate the regulation of mTORC1 by MDM4, a p53-inhibitor w...
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Article
Post-translational selective intracellular silencing of acetylated proteins with de novo selected intrabodies
PISA, generates intrabodies that selectively bind and interfere with the intracellular function of an acetylated version of a target protein.
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Article
Open AccessMicroRNA 19a replacement partially rescues fin and cardiac defects in zebrafish model of Holt Oram syndrome
Holt-Oram Syndrome (HOS) is an autosomal dominant heart-hand syndrome caused by mutations in the TBX5 gene, a transcription factor capable of regulating hundreds of cardiac-specific genes through complex transcri...
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Article
Open AccessTime dynamics of protein complexes in the AD11 transgenic mouse model for Alzheimer’s disease like pathology
Many approaches exist to integrate protein-protein interaction data with other sources of information, most notably with gene co-expression data, to obtain information on network dynamics. It is of interest to...
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Article
Open AccessproNGF/NGF mixtures induce gene expression changes in PC12 cells that neither singly produces
Growing evidence shows that, in vivo, the precursor of Nerve Growth Factor (NGF), proNGF, displays biological activities different from those of its mature NGF counterpart, mediated by distinct, and somewhat comp...
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Article
Open AccessParameter estimate of signal transduction pathways
The "inverse" problem is related to the determination of unknown causes on the bases of the observation of their effects. This is the opposite of the corresponding "direct" problem, which relates to the predic...
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Chapter and Conference Paper
SYMBIONIC: A European Initiative on the Systems Biology of the Neuronal Cell
To understand how genes, proteins and metabolites make up the whole organism, a systemic view is demanded, that is to conceive genes and proteins more as part of a network than as isolated entities. Molecular ...
