13 Result(s)
within
Ishnoor Kaur
English
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Article
Correction to: Connecting the dots between mitochondrial dysfunction and Parkinson’s disorder: focus mitochondria-targeting therapeutic paradigm in mitigating the disease severity
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Article
BIN1 in the Pursuit of Ousting the Alzheimer’s Reign: Impact on Amyloid and Tau Neuropathology
Alzheimer’s disease contributes to 60–70% of all dementia cases in the general population. Belonging to the BIN1/amphiphysin/RVS167 (BAR) superfamily, the bridging integrator (BIN1) has been identified to impa...
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“Cutting the Mustard” with Induced Pluripotent Stem Cells: An Overview and Applications in Healthcare Paradigm
Treatment of numerous ailments has been made accessible by the advent of genetic engineering, where the self-renewal property has unfolded the mysteries of regeneration, i.e., stem cells. This is narrowed down...
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A motley of possible therapies of the COVID-19: reminiscing the origin of the pandemic
The 2019 outbreak of corona virus disease began from Wuhan (China), transforming into a leading pandemic, posing an immense threat to the global population. The WHO coined the term nCOVID-19 for the disease on...
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Artificial intelligence as a fundamental tool in management of infectious diseases and its current implementation in COVID-19 pandemic
The world has never been prepared for global pandemics like the COVID-19, currently posing an immense threat to the public and consistent pressure on the global healthcare systems to navigate optimized tools, ...
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Targeting NLRP3 inflammasome as a chief instigator of obesity, contributing to local adipose tissue inflammation and insulin resistance
Inflammasome activity plays a vital role in various non-microbial disease states correlated with prolonged inflammation. NLRP3 inflammasome function and IL-1β formation are augmented in obesity and several obe...
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Connecting the dots between mitochondrial dysfunction and Parkinson’s disorder: focus mitochondria-targeting therapeutic paradigm in mitigating the disease severity
Mitochondria are unique cell organelles, which exhibit multifactorial roles in numerous cell physiological processes, significantly preserving the integrity of neural synaptic interconnections, mediating ATP p...
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Role of UPP pathway in amelioration of diabetes-associated complications
Type 2 diabetes (T2D) is one of the most widely spread metabolic disorder also called as “life style” disease. Due to the alarming number of patients, there is great need to therapies targeting functions which...
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The Interplay of ABC Transporters in Aβ Translocation and Cholesterol Metabolism: Implicating Their Roles in Alzheimer’s Disease
The occurrence of Alzheimer’s disease (AD) worldwide has been progressively accelerating at an alarming rate, without any successful therapeutic strategy for the disease mitigation. The complexity of AD pathog...
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Expatiating the molecular approaches of HMGB1 in diabetes mellitus: Highlighting signalling pathways via RAGE and TLRs
Diabetes mellitus (DM) has become one of the major healthcare challenges worldwide in the recent times and inflammation being one of its key pathogenic process/mechanism affect several body parts including the...
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Role of metallic pollutants in neurodegeneration: effects of aluminum, lead, mercury, and arsenic in mediating brain impairment events and autism spectrum disorder
Autism spectrum disorder (ASD) is a developmental disorder of the brain characterized by shortfall in the social portfolio of an individual and abbreviated interactive and communication aspects rendering stere...
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Unfolding Nrf2 in diabetes mellitus
In spite of much awareness, diabetes mellitus continues to remain one of major reasons for mortality and morbidity rate all over the globe. Free radicals cause oxidative stress which is responsible for causing...
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Exploring the molecular approach of COX and LOX in Alzheimer’s and Parkinson’s disorder
Neuroinflammation is well established biomarker for the major neurodegenerative like Alzheimer’s disease (AD) and Parkinson’s disease (PD). Cytokines/chemokines excite phospholipase A2 and cyclooxygenases (COX...
