-
Article
Evaluation and implementation of optimized antimicrobial dosing strategies in obese and underweight patients
We aimed to develop and implement dosing recommendations for antimicrobials in obese and underweight patients within an academic hospital, and assess their impact on antibiotic prescribing.
-
Article
Ceftazidime-related neurotoxicity in a patient with renal impairment: a case report and literature review
We present the case of a 67-year-old woman with severely reduced renal clearance suffering from ceftazidime-induced encephalopathy. Subsequently, we search the literature to review and describe the neurotoxici...
-
Article
Open AccessPersonalized Antifungal Therapy Through Model-Informed Precision Dosing of Posaconazole
Posaconazole is a pharmacotherapeutic pillar for prophylaxis and treatment of invasive fungal diseases. Dose individualization is of utmost importance as achieving adequate antifungal exposure is associated wi...
-
Article
Agreement Between a Colorimetric Assay and Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry for Quantifying Paracetamol Plasma Concentrations
Special populations, like geriatric patients, experience altered paracetamol pharmacokinetics (PK), complicating pain management. More PK research is essential to optimize paracetamol (acetaminophen) dosing. Y...
-
Article
Ten reasons for the presence of pharmacy professionals in the intensive care unit
-
Article
Open AccessPopulation Pharmacokinetics of Total and Unbound Isavuconazole in Critically Ill Patients: Implications for Adaptive Dosing Strategies
Isavuconazole is a broad-spectrum antifungal agent for the management of invasive fungal disease. Optimised drug exposure is critical for patient outcomes, specifically in the critically ill population. Solid ...
-
Article
Unravelling the Hepatic Elimination Mechanisms of Colistin
Colistin is an antibiotic which is increasingly used as a last-resort therapy in critically-ill patients with multidrug resistant Gram-negative infections. The purpose of this study was to evaluate the mechani...
-
Article
Insights into the Pharmacokinetics and Pharmacodynamics of Direct Oral Anticoagulants in Older Adults with Atrial Fibrillation: A Structured Narrative Review
Older adults, the fastest growing population, represent almost 50% of all users of direct oral anticoagulants (DOACs). Unfortunately, we have very little relevant pharmacological and clinical data on DOACs, es...
-
Article
Open AccessThe impact of extracorporeal membrane oxygenation on the exposure to isavuconazole: a plea for thorough pharmacokinetic evaluation
-
Article
Offering Guidance and Learning to Prescribers to Initiate Parenteral Nutrition using a Validated Electronic Decision TREE (OLIVE TREE)
Parenteral nutrition (PN) is recommended in patients nutritionally at risk and unable to receive oral or enteral nutrition. A standardized electronic PN order format could enhance appropriate PN prescribing. W...
-
Article
Open AccessEnd-users feedback and perceptions associated with the implementation of a clinical-rule based Check of Medication Appropriateness service
To support appropriate prescribing hospital-wide, the ‘Check of Medication Appropriateness’ (CMA) service was implemented at the University Hospitals Leuven. The CMA concerns a clinical rule based and pharmaci...
-
Article
Correction to: Perioperative antibiotic prophylaxis in long bone open fractures: the need for randomized controlled trials
A correction to this paper has been published: https://doi.org/10.1007/s00402-021-03847-7
-
Article
The TARGET trial as a plea for model-informed precision dosing of piperacillin/tazobactam in patients with sepsis
-
Article
Perioperative antibiotic prophylaxis in long bone open fractures: the need for randomized controlled trials
-
Article
Drug-related hospital admissions in older adults: comparison of the Naranjo algorithm and an adjusted version of the Kramer algorithm
To evaluate the ability of the adjusted Kramer algorithm in adjudicating causality of drug-related admissions (DRAs) in geriatric inpatients.
-
Article
Open AccessInteraction between posaconazole and flucloxacillin in a lung transplant patient: decrease in plasma exposure of posaconazole and possible undertreatment of invasive aspergillosis: case report
Variability in triazole plasma concentrations by drug interactions is well known. An interaction between voriconazole and flucloxacillin has already been described. In our case we observed a similar interactio...
-
Article
Open AccessOverall performance of a drug–drug interaction clinical decision support system: quantitative evaluation and end-user survey
Clinical decision support systems are implemented in many hospitals to prevent medication errors and associated harm. They are however associated with a high burden of false positive alerts and alert fatigue. ...
-
Article
Timeliness of administration of amoxicillin-clavulanic acid and meropenem in a large tertiary care centre
Background For amoxicillin-clavulanic acid and meropenem to be effective, concentrations must exceed the minimum inhibitory concentration of infecting pathogens. Objective To retrospectively evaluate time windows...
-
Article
Quantification and Explanation of the Variability of First-Dose Amikacin Concentrations in Critically Ill Patients Admitted to the Emergency Department: A Population Pharmacokinetic Analysis
There may be a difference between the determinants of amikacin exposure in emergency department (ED) versus intensive care (ICU) patients, and the peak amikacin concentration varies widely between patients. Mo...
-
Article
Posaconazole for prevention of invasive pulmonary aspergillosis in critically ill influenza patients (POSA-FLU): a randomised, open-label, proof-of-concept trial
Influenza-associated pulmonary aspergillosis (IAPA) is a frequent complication in critically ill influenza patients, associated with significant mortality. We investigated whether antifungal prophylaxis reduce...
