9 Result(s)

Article

DengueSeq: a pan-serotype whole genome amplicon sequencing protocol for dengue virus

The increasing burden of dengue virus on public health due to more explosive and frequent outbreaks highlights the need for improved surveillance and control. Genomic surveillance of dengue virus not only prov...

Chantal B. F. Vogels, Verity Hill, Mallery I. Breban, Chrispin Chaguza… in BMC Genomics (2024)

Article

Distinguishing features of long COVID identified through immune profiling

Post-acute infection syndromes may develop after acute viral disease¹. Infection with SARS-CoV-2 can result in the development of a post-acute infection syndrome known as long COVID. Individuals with long COVID f...

Jon Klein, Jamie Wood, Jillian R. Jaycox, Rahul M. Dhodapkar, Peiwen Lu… in Nature (2023)

Article

Lineage abundance estimation for SARS-CoV-2 in wastewater using transcriptome quantification techniques

Effectively monitoring the spread of SARS-CoV-2 mutants is essential to efforts to counter the ongoing pandemic. Predicting lineage abundance from wastewater, however, is technically challenging. We show that ...

Jasmijn A. Baaijens, Alessandro Zulli, Isabel M. Ott, Ioanna Nika… in Genome Biology (2022)

Article

Combining genomic and epidemiological data to compare the transmissibility of SARS-CoV-2 variants Alpha and Iota

SARS-CoV-2 variants shaped the second year of the COVID-19 pandemic and the discourse around effective control measures. Evaluating the threat posed by a new variant is essential for adapting response efforts ...

Mary E. Petrone, Jessica E. Rothman, Mallery I. Breban… in Communications Biology (2022)

Article

Reply to: A finding of sex similarities rather than differences in COVID-19 outcomes

Takehiro Takahashi, Mallory K. Ellingson, Patrick Wong, Benjamin Israelow… in Nature (2021)

Article

Diverse functional autoantibodies in patients with COVID-19

COVID-19 manifests with a wide spectrum of clinical phenotypes that are characterized by exaggerated and misdirected host immune responses^1–6. Although pathological innate immune activation is well-documented in ...

Eric Y. Wang, Tianyang Mao, Jon Klein, Yile Dai, John D. Huck, Jillian R. Jaycox… in Nature (2021)

Article

Sex differences in immune responses that underlie COVID-19 disease outcomes

There is increasing evidence that coronavirus disease 2019 (COVID-19) produces more severe symptoms and higher mortality among men than among women^1–5. However, whether immune responses against severe acute respi...

Takehiro Takahashi, Mallory K. Ellingson, Patrick Wong, Benjamin Israelow… in Nature (2020)

Article

Analytical sensitivity and efficiency comparisons of SARS-CoV-2 RT–qPCR primer–probe sets

The recent spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exemplifies the critical need for accurate and rapid diagnostic assays to prompt clinical and public health interventions. Curr...

Chantal B. F. Vogels, Anderson F. Brito, Anne L. Wyllie… in Nature Microbiology (2020)

Article

Longitudinal analyses reveal immunological misfiring in severe COVID-19

Recent studies have provided insights into the pathogenesis of coronavirus disease 2019 (COVID-19)^1–4. However, the longitudinal immunological correlates of disease outcome remain unclear. Here we serially analys...

Carolina Lucas, Patrick Wong, Jon Klein, Tiago B. R. Castro, Julio Silva… in Nature (2020)