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Irina M. Conboy
Life Sciences
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Article
Open AccessCorrection to: Old plasma dilution reduces human biological age: a clinical study
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Article
Open AccessOld plasma dilution reduces human biological age: a clinical study
This work extrapolates to humans the previous animal studies on blood heterochronicity and establishes a novel direct measurement of biological age. Our results support the hypothesis that, similar to mice, h...
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Article
Small-animal blood exchange is an emerging approach for systemic aging research
We describe a small-animal blood exchange approach developed for aging research as an alternative to heterochronic parabiosis or plasma injections. In parabiosis, animals are surgically coupled, which has seve...
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Article
Systemic induction of senescence in young mice after single heterochronic blood exchange
Ageing is the largest risk factor for many chronic diseases. Studies of heterochronic parabiosis, substantiated by blood exchange and old plasma dilution, show that old-age-related factors are systemically pro...
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Article
Open AccessPlasma dilution improves cognition and attenuates neuroinflammation in old mice
Our recent study has established that young blood factors are not causal, nor necessary, for the systemic rejuvenation of mammalian tissues. Instead, a procedure referred to as neutral blood exchange (NBE) tha...
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Article
Open AccessSkeletal muscle as an experimental model of choice to study tissue aging and rejuvenation
Skeletal muscle is among the most age-sensitive tissues in mammal organisms. Significant changes in its resident stem cells (i.e., satellite cells, SCs), differentiated cells (i.e., myofibers), and extracellul...
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Book
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Protocol
Preparation of Adult Muscle Fiber-Associated Stem/Precursor Cells
In our studies of muscle regeneration we have developed, modified, and optimized techniques to isolate and study the stem and precursor cells to muscle tissue. Our goals have been to obtain for study muscle fi...
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Protocol
Immuno-Analysis and FACS Sorting of Adult Muscle Fiber-Associated Stem/Precursor Cells
We describe the immunostaining methods we commonly use to detect the more robust cell markers identifying the various cell populations obtained by the enzymatic and or mechanical dissociation of muscle satelli...
