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  1. Article

    Open Access

    Cytokine-induced translocation of GRP78 to the plasma membrane triggers a pro-apoptotic feedback loop in pancreatic beta cells

    The 78-kDa glucose-regulated protein (GRP78) is an ubiquitously expressed endoplasmic reticulum chaperone, with a central role in maintaining protein homeostasis. Recently, an alternative role for GRP78 under ...

    Saurabh Vig, Mijke Buitinga, Dieter Rondas, Inne Crèvecoeur in Cell Death & Disease (2019)

  2. Article

    Correction: Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes

    Nat. Med. 22, 1482–1487 (2016); published online 31 October 2016; corrected after print 18 April 2017 In the version of this article initially published, the IA-2545–562 peptide identified as a target of a T c...

    Jenny Aurielle B Babon, Megan E DeNicola, David M Blodgett in Nature Medicine (2017)

  3. Article

    Early differences in islets from prediabetic NOD mice: combined microarray and proteomic analysis

    Type 1 diabetes is an endocrine disease where a long preclinical phase, characterised by immune cell infiltration in the islets of Langerhans, precedes elevated blood glucose levels and disease onset. Although...

    Inne Crèvecoeur, Valborg Gudmundsdottir, Saurabh Vig in Diabetologia (2017)

  4. Article

    Correction: Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes

    Nat. Med.; 10.1038/nm.4203; corrected online 15 November 2016 In the version of this article initially published online, the authors forgot to acknowledge the islet-isolation team at the Diabetes Research Inst...

    Jenny Aurielle B Babon, Megan E DeNicola, David M Blodgett in Nature Medicine (2017)

  5. No Access

    Article

    Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes

    Analysis of T cells isolated from patients with and without type 1 diabetes reveals reactivity to a range of native as well as post-translationally modified self-antigens only in individuals with T1D.

    Jenny Aurielle B Babon, Megan E DeNicola, David M Blodgett in Nature Medicine (2016)

  6. Article

    Open Access

    Foodborne cereulide causes beta cell dysfunction and apoptosis

    Roman Vangoitsenhoven, Dieter Rondas, Inne Crèvecoeur in Archives of Public Health (2014)