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Article
Open AccessCytokine-induced translocation of GRP78 to the plasma membrane triggers a pro-apoptotic feedback loop in pancreatic beta cells
The 78-kDa glucose-regulated protein (GRP78) is an ubiquitously expressed endoplasmic reticulum chaperone, with a central role in maintaining protein homeostasis. Recently, an alternative role for GRP78 under ...
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Article
Correction: Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes
Nat. Med. 22, 1482–1487 (2016); published online 31 October 2016; corrected after print 18 April 2017 In the version of this article initially published, the IA-2545–562 peptide identified as a target of a T c...
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Article
Early differences in islets from prediabetic NOD mice: combined microarray and proteomic analysis
Type 1 diabetes is an endocrine disease where a long preclinical phase, characterised by immune cell infiltration in the islets of Langerhans, precedes elevated blood glucose levels and disease onset. Although...
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Article
Correction: Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes
Nat. Med.; 10.1038/nm.4203; corrected online 15 November 2016 In the version of this article initially published online, the authors forgot to acknowledge the islet-isolation team at the Diabetes Research Inst...
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Article
Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes
Analysis of T cells isolated from patients with and without type 1 diabetes reveals reactivity to a range of native as well as post-translationally modified self-antigens only in individuals with T1D.
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Article
Open AccessFoodborne cereulide causes beta cell dysfunction and apoptosis