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Article
Open AccessRetraction Note: Quercetin-induced miR-200b-3p regulates the mode of self-renewing divisions in pancreatic cancer
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Article
Open AccessGlucocorticoid-induced microRNA-378 signaling mediates the progression of pancreatic cancer by enhancing autophagy
Glucocorticoids (GCs) are widely used in tumor therapy to reduce tumor growth, inflammation, edema, and other side effects. Controversially, GCs may also cause the progression of highly aggressive pancreatic d...
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Article
Open AccessBroccoli sprout supplementation in patients with advanced pancreatic cancer is difficult despite positive effects—results from the POUDER pilot study
Pancreatic ductal adenocarcinoma is a highly aggressive malignancy with short survival and limited therapeutic options. Broccoli sulforaphane is a promising new treatment due to the results of recent epidemiol...
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Article
Glycine protects partial liver grafts from Kupffer cell-dependent ischemia–reperfusion injury without negative effect on regeneration
Donor preconditioning with glycine prevents Kupffer cell-dependent reperfusion injury to liver grafts. Partial liver grafts need to regenerate and grow in size after transplantation; however, glycine inactivat...
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Article
The natural agent 4-vinylphenol targets metastasis and stemness features in breast cancer stem-like cells
Cancer stem-like cells (CSC) are regarded as the source of tumour origins, metastasis and drug resistance, and limits current treatment regimens. Previously, we reported the first study of the anti-angiogenic ...
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Article
Open AccessDexamethasone mediates pancreatic cancer progression by glucocorticoid receptor, TGFβ and JNK/AP-1
Glucocorticoids such as dexamethasone are widely co-prescribed with cytotoxic therapy because of their proapoptotic effects in lymphoid cancer, reduction of inflammation and edema and additional benefits. Conc...
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Article
Open AccessRETRACTED ARTICLE: Quercetin-induced miR-200b-3p regulates the mode of self-renewing divisions in pancreatic cancer
Cancer stem cells are suggested to contribute to the extremely poor prognosis of pancreatic ductal adenocarcinoma and dysregulation of symmetric and asymmetric stem cell division may be involved. Anticancer be...
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Article
Open AccessPilot study evaluating broccoli sprouts in advanced pancreatic cancer (POUDER trial) - study protocol for a randomized controlled trial
Pancreatic ductal adenocarcinoma (PDA) is one of the most aggressive malignancies with marked resistance to chemo- and radiotherapy. PDA-cancer stem cells (CSCs) are not targeted by current therapies and may b...
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Chapter
Sulforaphane as New Therapeutic Agent for Targeting of Cancer Stem Cells with Focus to Prostate and Pancreatic Cancer
Naturally occurring compounds with chemopreventive activity have received increasing attention in oncology. A number of epidemiological studies have reported an association of vegetable consumption and reduced...
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Chapter
Glucocorticoid-Mediated Apoptosis Resistance of Solid Tumors
More than a quarter of a century ago, the phenomenon of glucocorticoid-induced apoptosis in the majority of hematological cells was first recognized. More recently, glucocorticoid-induced antiapoptotic signali...
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Article
Regulation of differential pro- and anti-apoptotic signaling by glucocorticoids
More than a quarter of a century ago, the phenomenon of glucocorticoid-induced apoptosis in the majority of hematological cells was first recognized. More recently, glucocorticoid-induced antiapoptotic signali...
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Article
Open AccessCorticosteroid co-treatment induces resistance to chemotherapy in surgical resections, xenografts and established cell lines of pancreatic cancer
Chemotherapy for pancreatic carcinoma often has severe side effects that limit its efficacy. The glucocorticoid (GC) dexamethasone (DEX) is frequently used as co-treatment to prevent side effects of chemothera...
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Article
Autoamplification of apoptosis following ligation of CD95-L, TRAIL and TNF-α
CD95-L, TNF-α and TRAIL are death-inducing ligands (DILs) which may signal apoptosis via crosslinking of their cognate receptors. The present study shows that treatment of cells with agonistic mAB αAPO-1 (CD95...
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Article
Induction of apoptosis by IFNγ in human neuroblastoma cell lines through the CD95/CD95L autocrine circuit
The CD95 (APO-1/Fas) system can mediate apoptosis in immune cells as well as in tumour cells, where it may contribute to tumour immune-escape. On the other hand, its induction by anticancer drugs may lead to t...
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Article
JNK/SAPK activity contributes to TRAIL-induced apoptosis
We report here that JNK/SAPKs are activated by TRAIL in parallel to induction of apoptosis in human T and B cell lines. Death signaling as well as JNK/SAPK activation by TRAIL in these cells is FADD- and caspa...
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Article
Involvement of the CD95 (APO–1/Fas) receptor/ligand system in drug–induced apoptosis in leukemia cells
Cytotoxic drugs used in chemotherapy of leukemias and solid tumors cause apoptosis in target cells1,2. In lymphoid cells the CD95 (APO–1/Fas)/CD95 ligand (CD95–L) system is a key regulator of apoptosis3–6. Here w...
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Article
Transcriptional control of human papillomavirus type 18 oncogene expression in different cell lines: Role of transcription factor YY1
Binding of YY1 to the proximal fragment of the human papillomavirus type 18 (HPV-18) upstream regulatory region (URR) activates the oncogene expression of HPV-18 in HeLa cells, whereas in HepG2 cells this expr...
