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Article
Open AccessGermline Mutations and Ancestry in Prostate Cancer
Prostate cancer is the most frequently diagnosed non-cutaneous malignancy of men in the USA; notably, the incidence is higher among men of African, followed by European and Asian ancestry. Germline mutations a...
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Article
Open AccessGermline mutation landscape of DNA damage repair genes in African Americans with prostate cancer highlights potentially targetable RAD genes
In prostate cancer, emerging data highlight the role of DNA damage repair genes (DDRGs) in aggressive forms of the disease. However, DDRG mutations in African American men are not yet fully defined. Here, we p...
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Article
Open AccessIncreased frequency of germline BRCA2 mutations associates with prostate cancer metastasis in a racially diverse patient population
Germline mutations in BRCA2 have been linked to a higher risk of prostate cancer (PCa), and high frequency of BRCA1 and BRCA2 (BRCA1/2) gene alterations was recently reported in metastatic castration-resistant PC...
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Article
A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virus
Ludmila Prokunina-Olsson, Thomas O'Brien and colleagues report the discovery of a new gene, INFL4, encoding interferon-λ4, that is upstream of INFL3 (IL28B). A compound dinucleotide frameshift genetic variant in
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Article
Functional exploration of CCNE1 splicing forms as a possible link to bladder cancer susceptibility
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Article
Prostate stem cell antigen (PSCA) and risk of bladder cancer: linking genotypes to functional mechanisms
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Article
Prostate stem cell antigen (PSCA) and risk of bladder cancer: linking genotypes to functional mechanisms
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Article
Functional exploration of CCNE1splicing forms as a possible link to bladder cancer susceptibility
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Article
A novel functional variant in 8q24 is associated with regulation of prostate stem cell antigen (PSCA) gene expression and bladder cancer risk
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Article
A novel functional variant in 8q24 is associated with regulation of prostate stem cell antigen (PSCA) gene expression and bladder cancer risk
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Article
Open AccessNOTCH2 in breast cancer: association of SNP rs11249433 with gene expression in ER-positive breast tumors without TP53 mutations
A recent genome-wide association study (GWAS) has identified a single nucleotide polymorphism (SNP) rs11249433 in the 1p11.2 region as a novel genetic risk factor for breast cancer, and this association was st...
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Article
Association of Tumor Necrosis Factor-Alpha Gene Promoter Polymorphisms with Acute Viral Hepatitis in the Indian Population
The key elements that determine the host response to either the self-limited or a severe fulminant form of liver disease are unclear. We have investigated the potential association of single nucleotide polymor...
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Article
Association of single nucleotide polymorphisms (SNPs) in TNF-LTA locus with breast cancer risk in Indian population
Purpose Cytokine milieu of tumor microenvironment affects tumorigenesis in breast cancer. The aim of the present study was to investigate the potential association of functional single nu...
