6 Result(s)

Article

Parallelized multidimensional analytic framework applied to mammary epithelial cells uncovers regulatory principles in EMT

A proper understanding of disease etiology will require longitudinal systems-scale reconstruction of the multitiered architecture of eukaryotic signaling. Here we combine state-of-the-art data acquisition plat...

Indranil Paul, Dante Bolzan, Ahmed Youssef, Keith A. Gagnon… in Nature Communications (2023)

Article

The ubiquitin ligase Cullin5^SOCS2 regulates NDR1/STK38 stability and NF-κB transactivation

SOCS2 is a pleiotropic E3 ligase. Its deficiency is associated with gigantism and organismal lethality upon inflammatory challenge. However, mechanistic understanding of SOCS2 function is dismal due to our una...

Indranil Paul, Tanveer S. Batth, Diego Iglesias-Gato, Amna Al-Araimi… in Scientific Reports (2017)

Article

Erratum: OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo

Diego Iglesias-Gato, Yin-Choy Chuan, Ning Jiang, Charlotte Svensson… in Molecular Cancer (2015)

Article

OTUB1 de-ubiquitinating enzyme promotes prostate cancer cell invasion in vitro and tumorigenesis in vivo

Ubiquitination is a highly dynamic and reversible process with a central role in cell homeostasis. Deregulation of several deubiquitinating enzymes has been linked to tumor development but their specific role ...

Diego Iglesias-Gato, Yin-Choy Chuan, Ning Jiang, Charlotte Svensson… in Molecular Cancer (2015)