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    Article

    Mutant GTF2I induces cell transformation and metabolic alterations in thymic epithelial cells

    The pathogenesis of thymic epithelial tumors (TETs) is poorly understood. Recently we reported the frequent occurrence of a missense mutation in the GTF2I gene in TETs and hypothesized that GTF2I mutation might c...

    In-Kyu Kim, Guanhua Rao, **aoliang Zhao, Ruzong Fan… in Cell Death & Differentiation (2020)

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    Article

    Acquired SETD2 mutation and impaired CREB1 activation confer cisplatin resistance in metastatic non-small cell lung cancer

    Resistance to chemotherapy remains a critical barrier to effective cancer treatment. Although cisplatin is one of the most commonly used chemotherapeutic agents in the treatment of non-small cell lung cancer (...

    In-Kyu Kim, Justine N. McCutcheon, Guanhua Rao, Stephen V. Liu, Yves Pommier… in Oncogene (2019)