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  1. No Access

    Article

    Exploiting mesothelin in thymic carcinoma as a drug delivery target for anetumab ravtansine

    Thymic epithelial tumours (TETs) are rare tumours comprised of thymomas and thymic carcinoma. Novel therapies are needed, especially in thymic carcinoma where the 5-year survival rate hovers at 30%. Mesothelin...

    Vincent Chen, Shigeki Umemura, Yumin Han, Renuka Raman… in British Journal of Cancer (2022)

  2. No Access

    Article

    Mutant GTF2I induces cell transformation and metabolic alterations in thymic epithelial cells

    The pathogenesis of thymic epithelial tumors (TETs) is poorly understood. Recently we reported the frequent occurrence of a missense mutation in the GTF2I gene in TETs and hypothesized that GTF2I mutation might c...

    In-Kyu Kim, Guanhua Rao, **aoliang Zhao, Ruzong Fan… in Cell Death & Differentiation (2020)

  3. No Access

    Article

    Complete genome sequence of a novel reassortant H3N3 avian influenza virus

    Aquatic birds are known to be a reservoir for the most common influenza A viruses (IAVs). In the annual surveillance program, we collected the feces of migratory birds for the detection of IAVs in South Korea ...

    Tran Bac Le, Hey Kwon Kim, Hai Yen Le, Min-Chul Jeong, In-Kyu Kim… in Archives of Virology (2019)

  4. No Access

    Article

    Acquired SETD2 mutation and impaired CREB1 activation confer cisplatin resistance in metastatic non-small cell lung cancer

    Resistance to chemotherapy remains a critical barrier to effective cancer treatment. Although cisplatin is one of the most commonly used chemotherapeutic agents in the treatment of non-small cell lung cancer (...

    In-Kyu Kim, Justine N. McCutcheon, Guanhua Rao, Stephen V. Liu, Yves Pommier… in Oncogene (2019)

  5. Article

    Open Access

    Inhibition of AKT1 signaling promotes invasion and metastasis of non-small cell lung cancer cells with K-RAS or EGFR mutations

    Accumulating evidence supports a role of the PI3K-AKT pathway in the regulation of cell motility, invasion and metastasis. AKT activation is known to promote metastasis, however under certain circumstances, it...

    Guanhua Rao, Mariaelena Pierobon, In-Kyu Kim, Wei-Hsun Hsu… in Scientific Reports (2017)

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  6. Article

    Open Access

    Home range and movement of juvenile black-faced spoonbill Platalea minor in South Korea

    This study was conducted to clarify the size of the home range and movement distance of juvenile black-faced spoonbills from post-fledging until fall migration using a Global Positioning System (GPS)-wideband ...

    Jung-Hoon Kang, In Kyu Kim, Ki-Sup Lee, In-Ki Kwon… in Journal of Ecology and Environment (2017)

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  7. No Access

    Article

    A specific missense mutation in GTF2I occurs at high frequency in thymic epithelial tumors

    Giuseppe Giaccone and colleagues identify a recurrent missense mutation in GTF2I in a high percentage of thymic epithelial tumors. The mutation occurs more commonly in type A and AB thymomas and is associated wit...

    Iacopo Petrini, Paul S Meltzer, In-Kyu Kim, Marco Lucchi, Kang-Seo Park… in Nature Genetics (2014)

  8. No Access

    Article

    Roll-Bonded Tri-Layered Mg/Al/Stainless Steel Clad Composites and their Deformation and Fracture Behavior

    The deformation and fracture behaviors of roll-bonded tri-layered Mg/Al/stainless steel (SST) composite plates were studied. Brittle interfacial reaction compounds were observed at the Mg/Al interface upon ann...

    In-Kyu Kim, Sun Ig Hong in Metallurgical and Materials Transactions A (2013)

  9. No Access

    Article

    Involvement of superoxide radical in the impaired endothelium-dependent relaxation of cavernous smooth muscle in hypercholesterolemic rabbits

    Involvement of the superoxide radical in impaired relaxation of penile cavernous smooth muscle in hypercholesterolemia was investigated. New Zealand White rabbits (n = 40) were randomly divided into control and t...

    Sae Chul Kim, In Kyu Kim, Kyung Kenn Seo, Kwang ** Baek… in Urological Research (1997)

  10. No Access

    Article

    Bioconversion of hydrogen sulfide by free and immobilized cells ofChlorobium thiosulfatophilum

    The transformation of hydrogen sulfide into elementary sulfur and sulfate was investigated in a photo-bioreactor using autotropic bacteriaChlorobium thiosulfatophilum. The accumulations of sulfur and sulfate in t...

    Byung Woo Kim, In Kyu Kim, Ho Nam Chang in Biotechnology Letters (1990)