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Article
Open AccessSafety and efficacy of a novel anti-CD19 chimeric antigen receptor T cell product targeting a membrane-proximal domain of CD19 with fast on- and off-rates against non-Hodgkin lymphoma: a first-in-human study
Commercial anti-CD19 chimeric antigen receptor T-cell therapies (CART19) are efficacious against advanced B-cell non-Hodgkin lymphoma (NHL); however, most patients ultimately relapse. Several mechanisms contri...
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Article
SNP-based next-generation sequencing reveals low-level mixed chimerism after allogeneic hematopoietic stem cell transplantation
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Article
Open AccessEfficient strategy for the molecular diagnosis of intractable early-onset epilepsy using targeted gene sequencing
We intended to evaluate diagnostic utility of a targeted gene sequencing by using next generation sequencing (NGS) panel in patients with intractable early-onset epilepsy (EOE) and find the efficient analytica...
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Article
Open AccessThe effect of trauma and PTSD on telomere length: An exploratory study in people exposed to combat trauma
Telomere length has been suggested to be a cellular marker for age-related diseases as well as psychosocial stress. The present study investigated whether telomere length is associated with post-traumatic stre...
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Article
Evaluation of an amplicon-based next-generation sequencing panel for detection of BRCA1 and BRCA2 genetic variants
The recent advances in the next-generation sequencing (NGS) technology have enabled fast, accurate, and cost-effective genetic testing. Here, we evaluated the performance of a targeted NGS panel for BRCA1/2 seque...
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Article
Thermal decomposition characteristics of expired single-based propellant using a lab-scale tube furnace and a thermo-gravimetric analysis reactor
The Republic of Korea has a plan to construct an incineration facility for expired propellant from munitions including 155, 105 mm, and 8 in. howitzer shells. It is important to understand thermal characteris...
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Article
Open AccessProteomic analysis of kidneys from selenoprotein M transgenic rats in response to increased bioability of selenium
To characterize changes in global protein expression in kidneys of transgenic rats overexpressing human selenoprotein M (SelM) in response to increased bioabivility of selenium (Sel), total proteins extracted ...
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Article
Nicastrin Overexpression in Transgenic Mice Induces Aberrant Behavior and APP Processing
Nicastrin (NCT) is a component of the presenilin protein complex, which is involved in the cleavage of β-amyloid precursor protein (βAPP) and Notch. The aim of this study was to determine the manner in which o...
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Article
Selenium Significantly Inhibits Adipocyte Hypertrophy and Abdominal Fat Accumulation in OLETF Rats via Induction of Fatty Acid β-Oxidation
A combination of selenium (Se) with other trace element is associated with partially modulate fatty acid distribution as well as reduction of the body weight and feed efficiency. To investigate whether or not ...
