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Article
First-in-human imaging using [11C]MDTC: a radiotracer targeting the cannabinoid receptor type 2
We report findings from the first-in-human study of [11C]MDTC, a radiotracer developed to image the cannabinoid receptor type 2 (CB2R) with positron emission tomography (PET).
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Article
Correction to: Hetero-bivalent agents targeting FAP and PSMA
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Article
Hetero-bivalent agents targeting FAP and PSMA
We developed a theranostic radiopharmaceutical that engages two key cell surface proteases, fibroblast activation protein alpha (FAP) and prostate-specific membrane antigen (PSMA), each frequently overexpresse...
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Article
First-in-human neuroimaging of soluble epoxide hydrolase using [18F]FNDP PET
Soluble epoxide hydrolase (sEH) is an enzyme with putative effect on neuroinflammation through its influence on the homeostasis of polyunsaturated fatty acids and related byproducts. sEH is an enzyme that meta...
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Article
Non-invasive delivery of levodopa-loaded nanoparticles to the brain via lymphatic vasculature to enhance treatment of Parkinson’s disease
Levodopa (L-DOPA), a precursor of dopamine, is commonly prescribed for the treatment of the Parkinson’s disease (PD). However, oral administration of levodopa results in a high level of homocysteine in the per...
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Article
Open AccessNanoparticle-mediated tumor cell expression of mIL-12 via systemic gene delivery treats syngeneic models of murine lung cancers
Treatment of cancers in the lung remains a critical challenge in the clinic for which gene therapy could offer valuable options. We describe an effective approach through systemic injection of engineered polym...
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Article
Open AccessA prostate-specific membrane antigen (PSMA)-targeted prodrug with a favorable in vivo toxicity profile
Prostate-specific membrane antigen (PSMA) is a promising target for the treatment of advanced prostate cancer (PC) and various solid tumors. Although PSMA-targeted radiopharmaceutical therapy (RPT) has enabled...
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Article
Open AccessPET imaging of soluble epoxide hydrolase in non-human primate brain with [18F]FNDP
Soluble epoxide hydrolase (sEH) is a promising candidate positron emission tomography (PET) imaging biomarker altered in various disorders, including vascular cognitive impairment (VCI), Alzheimer’s disease (A...
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Article
177Lu-labeled low-molecular-weight agents for PSMA-targeted radiopharmaceutical therapy
To develop a prostate-specific membrane antigen (PSMA)-targeted radiotherapeutic for metastatic castration-resistant prostate cancer (mCRPC) with optimized efficacy and minimized toxicity employing the β-parti...
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Article
Follicle-stimulating hormone receptor in gynecological cancers
Expression of follicle-stimulating hormone receptor (FSHR) is normally restricted to the ovary and the testis, where FSH-dependent cell differentiation occurs. FSHR also is involved in the regulation of angiog...
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Article
Open AccessIn vitro characterization of pralidoxime transport and acetylcholinesterase reactivation across MDCK cells and stem cell-derived human brain microvascular endothelial cells (BC1-hBMECs)
Current therapies for organophosphate poisoning involve administration of oximes, such as pralidoxime (2-PAM), that reactivate the enzyme acetylcholinesterase. Studies in animal models have shown a low concent...
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Article
A red-shifted fluorescent substrate for aldehyde dehydrogenase
Selection of cells positive for aldehyde dehydrogenase (ALDH) activity from a green-fluorescent background is difficult with existing reagents. Here we report a red-shifted fluorescent substrate for ALDH, AldeRed...
