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  1. No Access

    Article

    Host antibacterial defense of 6–10 Gy γ-irradiated mice subjected to lentiviral vector-based Gas5 gene therapy

    Gut bacteria-associated sepsis is a serious concern in patients with gastrointestinal acute radiation syndrome (GIARS). In our previous studies, all mice exposed to 8 Gy of whole body γ-irradiation (8 Gy GIARS...

    Ichiaki Ito, Bradford D. Loucas, Sumihiro Suzuki, Makiko Kobayashi… in Gene Therapy (2023)

  2. No Access

    Article

    Oncogene addiction to GNAS in GNASR201 mutant tumors

    The GNASR201 gain-of-function mutation is the single most frequent cancer-causing mutation across all heterotrimeric G proteins, driving oncogenesis in various low-grade/benign gastrointestinal and pancreatic tum...

    Aditya More, Ichiaki Ito, Valsala Haridas, Saikat Chowdhury, Yue Gu… in Oncogene (2022)

  3. No Access

    Article

    Increased concentration of high-mobility group box 1 protein in milk is related to the severity of bovine mastitis

    High-mobility group box 1 (HMGB1) protein is the major component of the nonhistone nuclear protein group and is involved in nucleosome stabilization and transcription regulation. HMGB1 has recently been focuse...

    Yuki Furukawa, Tomohito Hayashi, Midori Mizuta… in Veterinary Research Communications (2011)

  4. No Access

    Article

    Lupus antibodies to the HMGB1 chromosomal protein: epitope map** and association with disease activity

    The high mobility group box 1 (HMGB1) protein is a non-histone chromosomal protein that acts as a potent proinflammatory cytokine when actively secreted from LPS- or TNF-activated macrophages, monocytes, and o...

    Ayako Hayashi, Hiroko Nagafuchi, Ichiaki Ito, Koichi Hirota… in Modern Rheumatology (2009)

  5. No Access

    Article

    The ubiquitin ligase CHIP acts as an upstream regulator of oncogenic pathways

    The ubiquitin ligase CHIP suppresses tumour growth and metastasis in breast cancer, and its expression inversely correlates with malignancy. The role of CHIP in cancer depends on degradation of the transcripti...

    Masashi Kajiro, Ryuichi Hirota, Yuka Nakajima, Kaori Kawanowa… in Nature Cell Biology (2009)