40 Result(s)

Article

Inverse agonists of H₁-receptors as promising antiallergy agents (a review)

The review summarizes published data and presents original results that illustrate the variety of antiallergic properties of second generation antihistamine drugs. General notions of inverse agonists of H₁-recept...

I. S. Gushchin in Pharmaceutical Chemistry Journal (2010)

Article

Diazin: a New Domestic Antiallergy Drug

P. V. Sergeev, I. S. Gushchin, M. É. Kaminka… in Pharmaceutical Chemistry Journal (2002)

Article

Dissociation of histamine releasing activity and T-cell reactivity of allergen conjugated with synthetic polymer

I. S. Gushchin, A. A. Babakhin, S. M. Andreev, A. W. Wheeler… in Inflammation Research (1997)

Article

Simulation of processes in an electrodynamic mass accelerator

Processes in a pulse plasma accelerator used as a mass accelerator are simulated in the magnetohydrodynamic approximation. Numerical calculations elucidate the dynamics of formation of a “plasma piston”. Two q...

I. S. Gushchin in Computational Mathematics and Modeling (1995)

Article

Histamine releasing activity of blood mononuclear cells is acquired by means of activation of mast cells

It has been shown that peripheral blood mononuclear cells (PBMC) obtained from atopic patients with acute clinical manifestations of pollinosis, atopic dermatitis or bronchial asthma, and preincubatedin vitro for...

I. S. Gushchin, N. S. Prozorovsky, E. M. Ignatyeva, V. G. Chitaeva… in Agents and Actions (1994)

Article

Application of direct methods to solve difference problems of gas-discharge physics

I. S. Gushchin, I. E. Kaporin in Computational Mathematics and Modeling (1994)

Article

Acceleration of a body in a channel in the quasi-one-dimensional magnetohydrodynamic approximation

I. S. Gushchin in Computational Mathematics and Modeling (1993)

Article

Phaeracological control of allergy at the stage of IgE antibody production

A. A. Babakhin, I. S. Gushchin, G. R. Morozova… in Pharmaceutical Chemistry Journal (1993)

Article

A method for calculation of a high-frequency discharge

I. S. Gushchin in Computational Mathematics and Modeling (1993)

Article

Discharge simulation in a high-frequency quasistatic field

I. S. Gushchin, S. A. Dvinin in Computational Mathematics and Modeling (1992)

Article

Possible role of mast cell membrane structures in the enhancement of spleen cell proliferation

The role of mast cells and their mediators in the regulation of immune processes is an area of current interest. In previous studies, we demonstrated that rat peritoneal mast cells and their supernatants enhan...

N. S. Prozorovsky, I. S. Gushchin, O. A. Jamshchikova in Agents and Actions (1992)

Article

Dissociation of histamine secretion and changes of oxidantantioxidant system indices in immunologically and nonimmunologically activated rat mast cells

The kinetics of changes in malondialdehyde (MDA) content, lipoxygenase (LO) activity, superoxide dismutase (SOD) activity, glutathione peroxidase activity and glutathione reductase activity during the course o...

I. S. Gushchin, O. R. Tsinkalovsky in Agents and Actions (1992)

Article

Status and prospects of development of antiallergic drugs

I. S. Gushchin, A. S. Saraf in Pharmaceutical Chemistry Journal (1992)

Article

Is the regulatory action of diuciphon-treated mononuclears dependent on the membrane-associated form of interleukin-2

N. S. Prozorovskii, V. P. Leskov… in Bulletin of Experimental Biology and Medic… (1991)

Article

Mast cell regulatory effect on lymphoid cell proliferation

It has been shown rat mast cells (MC) can modulate lymphocyte proliferationin vitro. Depending on concentrations tested both serosal MC and their supernatants enhanced the spontaneous and T-mitogen-induced prolif...

I. S. Gushchin, N. S. Prozorovsky, O. A. Yamshchikova, A. V. Kiselev in Agents and Actions (1991)

Article

Kinetics of oxygen metabolism indices in the course of histamine secretion from rat mast cells

In this study data are presented on the kinetics of changes in malondialdehyde content (MDA), lipoxygenase activity (LO), superoxide dismutase activity (SOD), glutathione peroxidase activity (GSH-Px) and gluta...

I. S. Gushchin, I. M. Petyaev, O. R. Tsinkalovsky in Agents and Actions (1990)

Article

Relationship between structure and activity of flavone derivatives possessing antiallergic activity

É. T. Oganesyan, I. S. Gushchin, S. R. Pershkov… in Pharmaceutical Chemistry Journal (1989)

Article

Histamine releasing action of polymyxin B and its analogs

D. I. Bairamashvili, V. G. Voitenko… in Bulletin of Experimental Biology and Medic… (1989)

Article

A polyfunctional molecule produced by the conjugation of a synthetic polyion-immunostimulant with specific antigen and an inhibitor of mast cell activation: Effects on histamine release

Polyfunctional molecules were prepared by appropriate conjugation of three moities (1) a polyion-immunostimulant (copolymer of N-vinylpyrrolidone with vinylamine-VP/VA), (2) an inhibitor of mediator secretion ...

I. S. Gushchin, V. G. Voitenko, B. D. Sviridov, N. L. Bogush in Agents and Actions (1989)

Article

Histamine releasing action of calcium ionophore 985-I

The polyether antibiotic 985-I induced histamine release from rat and mouse mast cells and human basophils. Histamine release induced by low concentrations (10–50 μM) of the ionophore was a selective (noncytotoxi...

I. S. Gushchin, A. I. Zebrev, V. G. Voitenko in Agents and Actions (1988)