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Article
Open AccessThe value of case reports in rare oncological scenarios: mixed method analysis of colorectal metastases from breast cancer
With improved survival of cancer patients, we increasingly encounter infrequent metastatic locations. While for the common metastatic locations both prognostic information as well as evidence-based guidelines ...
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Article
Open AccessLaboratory variation in the grading of dysplasia of duodenal adenomas in familial adenomatous polyposis patients
To prevent duodenal and ampullary cancer in familial adenomatous polyposis (FAP) patients, a diagnosis of high grade dysplasia (HGD) plays an important role in the clinical management. Previous research showed...
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Article
Open AccessInterobserver variation in the classification of tumor deposits in rectal cancer—is the use of histopathological characteristics the way to go?
The focus on lymph node metastases (LNM) as the most important prognostic marker in colorectal cancer (CRC) has been challenged by the finding that other types of locoregional spread, including tumor deposits ...
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Article
Open AccessIntestinal hypomotility in systemic sclerosis: a histological study into the sequence of events
The pathogenesis of intestinal involvement in systemic sclerosis (SSc) is thought to be a sequential process (vascular, neuronal, and consecutive muscular impairment), but understanding of the underlying histo...
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Article
Open AccessMore extensive lymphadenectomy in colon cancer; how far are we willing to go for a biomarker?
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Article
Open AccessIdentifying Biomarkers in Lymph Node Metastases of Esophageal Adenocarcinoma for Tumor-Targeted Imaging
Tumor-targeted imaging is a promising technique for the detection of lymph node metastases (LNM) and primary tumors. It remains unclear which biomarker is the most suitable target to distinguish malignant from...
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Article
Open AccessIdentification of barriers and facilitators in nationwide implementation of standardized structured reporting in pathology: a mixed method study
Standardized structured reporting (SSR) enables high-quality pathology reporting, but implementing SSR is slow. The objective of this study is to identify both barriers and facilitators that pathologists encou...
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Article
Open AccessImproving preoperative detection of synchronous liver metastases in pancreatic cancer with combined contrast-enhanced and diffusion-weighted MRI
To explore the value of gadolinium-enhanced MRI combined with diffusion-weighted MRI (Gd-enhanced MRI with DWI) in addition to contrast-enhanced CT (CECT) for detection of synchronous liver metastases for pote...
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Article
Open AccessThe impact of mammography screening programmes on incidence of advanced breast cancer in Europe: a literature review
Observational studies have reported conflicting results on the impact of mammography service screening programmes on the advanced breast cancer rate (ABCR), a correlation that was firmly established in randomi...
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Article
Open AccessChildhood neuroendocrine tumours: a descriptive study revealing clues for genetic predisposition
Neuroendocrine tumours (NETs) are rare in children and limited data are available. We aimed to specify tumour and patient characteristics and to investigate the role of genetic predisposition in the aetiology ...
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Article
Open AccessA multi-centred randomised trial of radical surgery versus adjuvant chemoradiotherapy after local excision for early rectal cancer
Rectal cancer surgery is accompanied with high morbidity and poor long term functional outcome. Screening programs have shown a shift towards more early staged cancers. Patients with early rectal cancer can po...
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Article
Open AccessRecommendations for reporting histopathology studies: a proposal
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Article
Open AccessVascular endothelial growth factor D expression is a potential biomarker of bevacizumab benefit in colorectal cancer
Bevacizumab prolongs progression-free survival (PFS) in patients with metastatic colorectal cancer. We analysed the protein expression levels of vascular endothelial growth factor (VEGF) ligands and receptors ...
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Article
Open AccessMitochondrial microsatellite instability in patients with metastatic colorectal cancer
Mitochondrial microsatellite instability (mtMSI), a change in length in mtDNA microsatellite sequences between normal and tumor tissue, has been described as a frequent occurrence in colorectal cancer (CRC). W...
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Article
EURECCA consensus conference highlights about colorectal cancer clinical management: the pathologists expert review
Care for patients with colon and rectal cancer has improved in the last 20 years; however, a considerable variation still exists in cancer management and outcome between European countries. Large variation is ...
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Chapter
What Is “Good Quality” in Rectal Cancer Surgery? The Pathologist’s Perspective
High local recurrence rates were a major problem in rectal cancer treatment, with between 30 and 50 % of patients affected, resulting in a very poor quality of life and short survival of patients with rectal c...
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Chapter
Predicting Lymph Node Metastases in pT1 Rectal Cancer
With the widespread introduction of population screening for colorectal cancer in Europe, the number of early rectal cancers is expected to increase. In the past, approximately 25 % of rectal cancers presented...
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Article
Reduction in rate of node metastases with breast screening: consistency of association with tumor size
Population screening has brought about changes in both the incidence and mortality rates of patients with breast cancer. Large numbers of small screen-detected tumors have inspired discussions about overdiagno...
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Article
Open AccessKRAS mutation analysis: a comparison between primary tumours and matched liver metastases in 305 colorectal cancer patients
KRAS mutation is a negative predictive factor for treatment with anti-epidermal growth factor receptor antibody in metastatic colorectal cancer (CRC). KRAS mutation analysis is usually performed on primary tumour...
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Article
Open AccessClinicopathological features and outcome in advanced colorectal cancer patients with synchronous vs metachronous metastases
Synchronous metastases of colorectal cancer (CRC) are considered to be of worse prognostic value compared with metachronous metastases, but only few and conflicting data have been reported on this issue.
