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Article
Yin-Yang 1 and Yin-Yang 2 exert opposing effects on the promoter activity of interleukin 4
Interleukin (IL)-4 acts on T cells as a growth and activation factor, and promotes the differentiation of type 2 T helper cells. In T cells, expression of the gene encoding IL-4 is regulated by inducible or co...
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Article
Bromopropane compounds inhibit osteogenesis by ERK-dependent Runx2 inhibition in C2C12 cells
Bromopropane (BP) is a halogenated alkan compound used in various industries as chemical intermediates, extraction solvents, and degreasing compounds. Halogenated alkan compounds can damage the nervous system,...
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Article
Inhibition of osteoblastic differentiation by warfarin and 18-α-glycyrrhetinic acid
Anticoagulation therapy with vitamin K antagonists such as warfarin is widely used to prevent and treat stroke in patients with chronic atrial fibrillation or mechanical heart valves. Because vitamin K is an e...
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Article
PKA-Mediated stabilization of FoxH1 negatively regulates ERα activity
Estrogen receptor α (ERα) mediates the mitogenic effects of estrogen. ERα signaling regulates the normal growth and differentiation of mammary tissue, but uncontrolled ERα activation increases the risk to brea...