40 Result(s)
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Hyun-** Sim
English
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Article
Open AccessPhenylacetic acid, an anti-vaginitis metabolite produced by the vaginal symbiotic bacterium Chryseobacterium gleum
The human microbiome contains genetic information that regulates metabolic processes in response to host health and disease. While acidic vaginal pH is maintained in normal conditions, the pH level increases i...
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Open AccessOrthoID: profiling dynamic proteomes through time and space using mutually orthogonal chemical tools
Identifying proteins at organelle contact sites, such as mitochondria-associated endoplasmic reticulum membranes (MAM), is essential for understanding vital cellular processes, yet challenging due to their dyn...
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Open AccessThe LKB1–TSSK1B axis controls YAP phosphorylation to regulate the Hippo–YAP pathway
The Hippo pathway’s main effector, Yes-associated protein (YAP), plays a crucial role in tumorigenesis as a transcriptional coactivator. YAP’s phosphorylation by core upstream components of the Hippo pathway, ...
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Open AccessUnderstanding the molecular mechanism of pathogenic variants of BIR2 domain in XIAP-deficient inflammatory bowel disease
X-linked inhibitor of apoptosis protein (XIAP) deficiency causes refractory inflammatory bowel disease. The XIAP protein plays a pivotal role in the pro-inflammatory response through the nucleotide-binding oli...
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Open AccessEffects of fine particulate matter on bone marrow-conserved hematopoietic and mesenchymal stem cells: a systematic review
The harmful effects of fine particulate matter ≤2.5 µm in size (PM2.5) on human health have received considerable attention. However, while the impact of PM2.5 on the respiratory and cardiovascular systems has be...
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Open AccessStatistically unbiased prediction enables accurate denoising of voltage imaging data
Here we report SUPPORT (statistically unbiased prediction utilizing spatiotemporal information in imaging data), a self-supervised learning method for removing Poisson–Gaussian noise in voltage imaging data. S...
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Open AccessInvestigating the electrical crosstalk effect between pixels in high-resolution organic light-emitting diode microdisplays
Organic light-emitting diode (OLED) microdisplays have received great attention owing to their excellent performance for augmented reality/virtual reality devices applications. However, high pixel density of O...
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Open AccessLong-term efficacy of anti-IL-4 receptor antibody in a patient with aspirin-exacerbated respiratory disease and IgG4-related disease
Aspirin-exacerbated respiratory disease (AERD) and IgG4-related disease (IgG4RD) share a common pathway of Th2-mediated immune mechanism; there have been several cases of IgG4RD developed in patients with asth...
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Open AccessMorphological and morphometric study of the scapulae of Korean wild deer
Korean water deer (Hydropotes inermis argyropus; Heude, 1884) and Siberian roe deer (Capreolus pygargus; Pallas, 1771) are Korean wild deer classified in the tribe Capreolini. C. pygargus in Korea were previously...
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Open AccessPrion infection modulates hematopoietic stem/progenitor cell fate through cell-autonomous and non-autonomous mechanisms
Studies of PrPC-derived prion disease generally focus on neurodegeneration. However, little is known regarding the modulation of hematopoietic stem progenitor cells (HSPCs) that express PrPC in prion infection. A...
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Open AccessButyrate potentiates Enterococcus faecalis lipoteichoic acid-induced inflammasome activation via histone deacetylase inhibition
Enterococcus faecalis, a Gram-positive opportunistic pathogen having lipoteichoic acid (LTA) as a major virulence factor, is closely associated with refractory apical periodontitis. Short-chain fatty acids (SCFAs...
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Open AccessCombined IgE neutralization and Bifidobacterium longum supplementation reduces the allergic response in models of food allergy
IgE is central to the development of allergic diseases, and its neutralization alleviates allergic symptoms. However, most of these antibodies are based on IgG1, which is associated with an increased risk of f...
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Open AccessAuthor Correction: Human cardiac stem cells rejuvenated by modulating autophagy with MHY-1685 enhance the therapeutic potential for cardiac repair
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Open AccessInfluence of sintering temperatures on microstructure and electrochemical performances of LiNi0.93Co0.04Al0.03O2 cathode for high energy lithium ion batteries
In this study, we present a method for synthesizing Ni-rich LiNi0.93Co0.04Al0.03O2 (NCA) with a high-energy cathode material by the solid-phase method. The sintering temperature plays a very important role in the...
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Open AccessIdentification of nontuberculous mycobacteria isolated from household showerheads of patients with nontuberculous mycobacteria
This study aimed to examine whether nontuberculous mycobacteria (NTM) inside household showerheads are identical to those in patients with NTM-pulmonary disease (PD) since household water is one of the potenti...
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Open AccessMachine-learning algorithm that can improve the diagnostic accuracy of septic arthritis of the knee
Prompt diagnosis and treatment of septic arthritis of the knee is crucial. Nevertheless, the quality of evidence for the diagnosis of septic arthritis is low. In this study, the authors developed a machine lea...
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Open AccessDual function Li-reactive coating from residual lithium on Ni-rich NCM cathode material for Lithium-ion batteries
In this study, lithium phosphate (Li3PO4) is coated on the surface of Ni-rich LiNi0.91Co0.06Mn0.03O2 cathode material to enhance its cyclability and rate performance. The process is carried-out by achieving dual ...
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Open AccessHuman cardiac stem cells rejuvenated by modulating autophagy with MHY-1685 enhance the therapeutic potential for cardiac repair
Stem cell-based therapies with clinical applications require millions of cells. Therefore, repeated subculture is essential for cellular expansion, which is often complicated by replicative senescence. Cellula...
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Open AccessHypothermic treatment reduces matrix metalloproteinase-9 expression and damage in the liver following asphyxial cardiac arrest in rats
Hypothermic treatment is known to protect organs against cardiac arrest (CA) and improves survival rate. However, few studies have evaluated the effects of hypothermia on CA-induced liver damages. This study w...
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Open AccessRedefining differential roles of MAO-A in dopamine degradation and MAO-B in tonic GABA synthesis
Monoamine oxidase (MAO) is believed to mediate the degradation of monoamine neurotransmitters, including dopamine, in the brain. Between the two types of MAO, MAO-B has been believed to be involved in dopamine...
