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Article
Open AccessAddition of cariogenic pathogens to complex oral microflora drives significant changes in biofilm compositions and functionalities
Dental caries is a microbe and sugar-mediated biofilm-dependent oral disease. Of particular significance, a virulent type of dental caries, known as severe early childhood caries (S-ECC), is characterized by t...
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Article
Open AccessIncongruence between dominant commensal donor microbes in recipient feces post fecal transplant and response to anti-PD-1 immunotherapy
To understand inter-individual variability of fecal microbe transplantation (FMT) to enhance anti-PD-1 immunotherapy (IT) for melanoma, we analyzed the data sets from two recent publications with a microbial s...
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Article
The oral microbiota: dynamic communities and host interactions
The dynamic and polymicrobial oral microbiome is a direct precursor of diseases such as dental caries and periodontitis, two of the most prevalent microbially induced disorders worldwide. Distinct microenviron...
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Article
Targeting microbial biofilms: current and prospective therapeutic strategies
Biofilms harbour complex structural and biological attributes, such as the presence of an extracellular polymeric matrix, physical and chemical heterogeneity a...
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Article
Open AccessInfluences of naturally occurring agents in combination with fluoride on gene expression and structural organization of Streptococcus mutans in biofilms
The association of specific bioactive flavonoids and terpenoids with fluoride can modulate the development of cariogenic biofilms by simultaneously affecting the synthesis of exopolysaccharides (EPS) and acid ...