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  1. Article

    Open Access

    Addition of cariogenic pathogens to complex oral microflora drives significant changes in biofilm compositions and functionalities

    Dental caries is a microbe and sugar-mediated biofilm-dependent oral disease. Of particular significance, a virulent type of dental caries, known as severe early childhood caries (S-ECC), is characterized by t...

    Yuan Liu, Scott G. Daniel, Hye-Eun Kim, Hyun Koo, Jonathan Korostoff in Microbiome (2023)

  2. Article

    Open Access

    Incongruence between dominant commensal donor microbes in recipient feces post fecal transplant and response to anti-PD-1 immunotherapy

    To understand inter-individual variability of fecal microbe transplantation (FMT) to enhance anti-PD-1 immunotherapy (IT) for melanoma, we analyzed the data sets from two recent publications with a microbial s...

    Hyunmin Koo, Casey D. Morrow in BMC Microbiology (2021)

  3. No Access

    Article

    The oral microbiota: dynamic communities and host interactions

    The dynamic and polymicrobial oral microbiome is a direct precursor of diseases such as dental caries and periodontitis, two of the most prevalent microbially induced disorders worldwide. Distinct microenviron...

    Richard J. Lamont, Hyun Koo, George Hajishengallis in Nature Reviews Microbiology (2018)

  4. No Access

    Article

    Targeting microbial biofilms: current and prospective therapeutic strategies

  5. Biofilms harbour complex structural and biological attributes, such as the presence of an extracellular polymeric matrix, physical and chemical heterogeneity a...

  6. Hyun Koo, Raymond N. Allan, Robert P. Howlin, Paul Stoodley in Nature Reviews Microbiology (2017)

  7. Article

    Open Access

    Influences of naturally occurring agents in combination with fluoride on gene expression and structural organization of Streptococcus mutans in biofilms

    The association of specific bioactive flavonoids and terpenoids with fluoride can modulate the development of cariogenic biofilms by simultaneously affecting the synthesis of exopolysaccharides (EPS) and acid ...

    Jae-Gyu Jeon, Marlise I Klein, ** **ao, Stacy Gregoire in BMC Microbiology (2009)