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Article
Open AccessTranscriptome analysis of cynomolgus macaques throughout their lifespan reveals age-related immune patterns
Despite the different perspectives by diverse research sectors spanning several decades, aging research remains uncharted territory for human beings. Therefore, we investigated the transcriptomic characteristi...
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Article
Open AccessSense-oriented AluYRa1 elements provide a lineage-specific transcription environment for polyadenylation
Transposable elements cause alternative splicing (AS) in different ways, contributing to transcript diversification. Alternative polyadenylation (APA), one of the AS events, is related to the generation of mRN...
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Article
Open AccessA single mutation in the ACTR8 gene associated with lineage-specific expression in primates
Alternative splicing (AS) generates various transcripts from a single gene and thus plays a significant role in transcriptomic diversity and proteomic complexity. Alu elements are primate-specific transposable el...
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Article
Open AccessCooperative evolution of two different TEs results in lineage-specific novel transcripts in the BLOC1S2 gene
The BLOC1S2 gene encodes the multifunctional protein BLOS2, a shared subunit of two lysosomal trafficking complexes: i) biogenesis of lysosome-related organelles complex-1 and i) BLOC-1-related complex. In our pr...
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Article
Open AccessSuccessful application of human-based methyl capture sequencing for methylome analysis in non-human primate models
The characterization of genomic or epigenomic variation in human and animal models could provide important insight into pathophysiological mechanisms of various diseases, and lead to new developments in diseas...
