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Article
Open AccessAssociation between circulating ECM-associated molecules and cardiovascular outcomes in hemodialysis patients: a multicenter prospective cohort study
Hemodialysis patients are susceptible to cardiovascular remodeling, which increases the risk of cardiovascular morbidity and mortality. Circulating extracellular matrix (ECM)-associated molecules increase duri...
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Article
Open AccessProteomic profiling of protein expression changes after 3 months-exercise in ESRD patients on hemodialysis
The prevalence of chronic kidney disease (CKD) is steadily increasing, and it is a global health burden. Exercise has been suggested to improve physical activity and the quality of life in patients with CKD, e...
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Article
Open AccessPINK1 deficiency impairs osteoblast differentiation through aberrant mitochondrial homeostasis
PTEN-induced kinase 1 (PINK1) is a serine/threonine-protein kinase in mitochondria that is critical for mitochondrial quality control. PINK1 triggers mitophagy, a selective autophagy of mitochondria, and is in...
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Article
Open AccessDietary phytochemicals as a promising nutritional strategy for sarcopenia: a systematic review and meta-analysis of randomized controlled trials
The decline in skeletal muscle mass and strength, also called sarcopenia, accelerates with age, leading to negative health outcomes and poor quality of life. Diet is important to promote health and plays a key...
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Article
Open AccessThe adipokine Retnla deficiency increases responsiveness to cardiac repair through adiponectin-rich bone marrow cells
Resistin-like alpha (Retnla) is a member of the resistin family and known to modulate fibrosis and inflammation. Here, we investigated the role of Retnla in the cardiac injury model. Myocardial infarction (MI)...
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Article
Open AccessCoulomb drag transistor using a graphene and MoS2 heterostructure
Two-dimensional (2D) heterostructures often provide extraordinary carrier transport as exemplified by superconductivity or excitonic superfluidity. Recently, a double-layer graphene (Gr) separated by few-layer...
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Article
Open AccessAdjuvant role of macrophages in stem cell-induced cardiac repair in rats
Bone marrow-derived mesenchymal stem cells (BMMSCs) are used extensively for cardiac repair and interact with immune cells in the damaged heart. Macrophages are known to be modulated by stem cells, and we hypo...
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Article
Open AccessLINCS L1000 dataset-based repositioning of CGP-60474 as a highly potent anti-endotoxemic agent
Sepsis is one of the most common clinical syndromes that causes death and disability. Although many studies have developed drugs for sepsis treatment, none have decreased the mortality rate. The aim of this st...
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Article
Open AccessBeneficial effect of statins in patients receiving chronic hemodialysis following percutaneous coronary intervention: A nationwide retrospective cohort study
The cardiovascular diseases are the leading cause of mortality in end-stage renal disease (ESRD) patients. However, roles of statins are still controversial in dialysis-dependent ESRD patients regardless of ha...
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Article
Open AccessChloroquine and amodiaquine enhance AMPK phosphorylation and improve mitochondrial fragmentation in diabetic tubulopathy
We investigated the effects of chloroquine (CQ) and amodiaquine (AQ) on AMPK phosphorylation in renal tubular cells in a diabetic environment in vivo and in vitro. We also examined whether CQ- or AQ-mediated AMPK...
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Article
Open AccessNatural product derivative BIO promotes recovery after myocardial infarction via unique modulation of the cardiac microenvironment
The cardiac microenvironment includes cardiomyocytes, fibroblasts and macrophages, which regulate remodeling after myocardial infarction (MI). Targeting this microenvironment is a novel therapeutic approach fo...
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Article
Open AccessMisorientation-angle-dependent electrical transport across molybdenum disulfide grain boundaries
Grain boundaries in monolayer transition metal dichalcogenides have unique atomic defect structures and band dispersion relations that depend on the inter-domain misorientation angle. Here, we explore misorien...
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Article
Open Access5-Azacytidine modulates interferon regulatory factor 1 in macrophages to exert a cardioprotective effect
Macrophages are actively involved in inflammatory responses during the progression of cardiac injury, including myocardial infarction (MI). A previous study showed that 5-azacytidine (5AZ), a DNA methylation i...
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Article
Open AccessMesenchymal stem cells reciprocally regulate the M1/M2 balance in mouse bone marrow-derived macrophages
Mesenchymal stem cells (MSCs) have been widely studied for their applications in stem cell-based regeneration. During myocardial infarction (MI), infiltrated macrophages have pivotal roles in inflammation, ang...
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Article
Open AccessRestoration of angiogenic capacity of diabetes-insulted mesenchymal stem cells by oxytocin
Angiogenesis is the main therapeutic mechanism of cell therapy for cardiovascular diseases, but diabetes is reported to reduce the function and number of progenitor cells. Therefore, we studied the effect of s...
