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Article
Open AccessmRNA vaccine encoding Gn provides protection against severe fever with thrombocytopenia syndrome virus in mice
We developed a promising mRNA vaccine against severe fever with thrombocytopenia syndrome (SFTS), an infectious disease caused by the SFTS virus that is primarily transmitted through tick bites. Administration...
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Article
Open AccessAnalyzing immune responses to varied mRNA and protein vaccine sequences
In response to the COVID-19 pandemic, different types of vaccines, such as inactive, live-attenuated, messenger RNA (mRNA), and protein subunit, have been developed against SARS-CoV-2. This has unintentionally...
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Article
Open AccessHeterologous vaccination utilizing viral vector and protein platforms confers complete protection against SFTSV
Severe fever with thrombocytopenia syndrome virus was first discovered in 2009 as the causative agent of severe fever with thrombocytopenia syndrome. Despite its potential threat to public health, no prophylac...
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Article
Open AccessAdjuvant effect of IRES-based single-stranded RNA on melanoma immunotherapy
Adjuvant therapies such as radiation therapy, chemotherapy, and immunotherapy are usually given after cancer surgery to improve the survival of cancer patients. However, despite advances in several adjuvant th...
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Article
Open AccessEffective inactivated influenza vaccine for the elderly using a single-stranded RNA-based adjuvant
There is an unmet need for new influenza vaccine strategies that compensate for impaired vaccine responses in elderly individuals. Here, we evaluated the effectiveness of a single-stranded RNA (ssRNA) as an ad...
