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Article
COCH-related autosomal dominant nonsyndromic hearing loss: a phenotype–genotype study
This phenotype–genotype study aimed to investigate the extent of audioprofile variability related to cochlin major domains and to identify potential ethnic-specific differences associated with COCH-related hearin...
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Article
Open AccessA designed fusion tag for soluble expression and selective separation of extracellular domains of fibroblast growth factor receptors
Fibroblast growth factor receptors (FGFRs) generate various transduction signals by interaction with fibroblast growth factors (FGFs) and are involved in various biological functions such as cell proliferation...
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Article
Soluble overexpression of a flagellin derivative from Salmonella enterica using synonymous codon substitutions of 5′-coding region in Escherichia coli
To obtain a recombinant flagellin derivative CBLB502, expressed in functionally soluble form, the technology of library construction and screening of synonymous codon variants was employed, and its expression,...
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Article
Open AccessRare KCNQ4 variants found in public databases underlie impaired channel activity that may contribute to hearing impairment
KCNQ4 is frequently mutated in autosomal dominant non-syndromic hearing loss (NSHL), a typically late-onset, initially high-frequency loss that progresses over time (DFNA2). Most KCNQ4 mutations linked to hearing...
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Article
Open AccessWhole-exome sequencing identifies two novel mutations in KCNQ4 in individuals with nonsyndromic hearing loss
Mutations in potassium voltage-gated channel subfamily Q member 4 (KCNQ4) are etiologically linked to a type of nonsyndromic hearing loss, deafness nonsyndromic autosomal dominant 2 (DFNA2). We performed whole-ex...
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Article
Open AccessWhole-exome sequencing identified a missense mutation in WFS1 causing low-frequency hearing loss: a case report
Low-frequency nonsyndromic hearing loss (LF-NSHL) is a rare, inherited disorder. Here, we report a family with LF-NSHL in whom a missense mutation was found in the Wolfram syndrome 1 (WFS1) gene.
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Article
Effective pedestrian detection using deformable part model based on human model
Recently, pedestrian detection systems have become an important technology in the development of the advanced driver assistance system (ADAS) for the autonomous car. The histogram of oriented gradients (HOG) i...
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Article
Open AccessThe different role of intratumoral and peritumoral lymphangiogenesis in gastric cancer progression and prognosis
Tumor-induced lymphangiogenesis plays a crucial role in metastasis and tumor progression. However, the significance of intratumoral lymphovascular density (I-LVD) and peritumoral lymphovascular density (P-LVD)...
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Article
Open AccessThe novel histone deacetylase inhibitor, N-hydroxy-7-(2-naphthylthio) hepatonomide, exhibits potent antitumor activity due to cytochrome-c-release-mediated apoptosis in renal cell carcinoma cells
Epigenetic modifications play a critical role in the regulation of all DNA-based processes, such as transcription, repair, and replication. Inappropriate histone modifications can result in dysregulation of ce...
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Article
Catalytic performance of polymer-supported ionic liquids in the cycloaddition of carbon dioxide to allyl glycidyl ether
Ionic liquids immobilized onto structurally modified Merrifield peptide resin (MPR) were prepared through the reaction of imidazole with alkoxylated MPR. Elemental analysis and SEM images showed that the immob...
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Article
Microwave Assisted Synthesis of Cyclic Carbonate Using Homogeneous and Heterogeneous Ionic Liquid Catalysts
A comparative study was effectuated between the catalytic performance of homogeneous and silica supported ionic liquids (SSILs) for the cycloaddition of epoxides and CO2 under microwave irradiation by varying the...
