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Article
Open AccessNetwork propagation-based prioritization of long tail genes in 17 cancer types
The diversity of genomic alterations in cancer poses challenges to fully understanding the etiologies of the disease. Recent interest in infrequent mutations, in genes that reside in the “long tail” of the mut...
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Article
Open AccessGermline variant burden in cancer genes correlates with age at diagnosis and somatic mutation burden
Cancers harbor many somatic mutations and germline variants, we hypothesized that the combined effect of germline variants that alter the structure, expression, or function of protein-coding regions of cancer-...
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Article
Exploring single-cell data with deep multitasking neural networks
It is currently challenging to analyze single-cell data consisting of many cells and samples, and to address variations arising from batch effects and different sample preparations. For this purpose, we presen...
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Article
Open AccessGenomics and data science: an application within an umbrella
Data science allows the extraction of practical insights from large-scale data. Here, we contextualize it as an umbrella term, encompassing several disparate subdomains. We focus on how genomics fits as a spec...
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Chapter and Conference Paper
Computational Evaluation of Protein Energy Functions
Proteins are organic compounds made up of chains of amino acids that fold into complex 3-dimensional structures based on their chemical and physical properties. A protein is characterized by its 3D structure, ...
