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Article
Open AccessISX-9 potentiates CaMKIIδ-mediated BMAL1 activation to enhance circadian amplitude
Circadian dysregulation associates with numerous diseases including metabolic dysfunction, sleep disorder, depression and aging. Given that declined circadian amplitude is a trait commonly found with compromis...
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Article
Open AccessInfluenza a virus NS1 resembles a TRAF3-interacting motif to target the RNA sensing-TRAF3-type I IFN axis and impair antiviral innate immunity
Influenza A virus (IAV) evolves strategies to counteract the host antiviral defense for establishing infection. The influenza A virus (IAV) non-structural protein 1 (NS1) is a key viral factor shown to counter...
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Article
Open AccessNeurodegeneration-associated FUS is a novel regulator of circadian gene expression
Circadian rhythms are oscillating physiological and behavioral changes governed by an internal molecular clock, and dysfunctions in circadian rhythms have been associated with ageing and various neurodegenerat...
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Article
Open AccessPhysiological links of circadian clock and biological clock of aging
Circadian rhythms orchestrate biochemical and physiological processes in living organisms to respond the day/night cycle. In mammals, nearly all cells hold self-sustained circadian clocks meanwhile couple the ...
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Article
Open AccessMutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction
Dysregulation of ribosome biogenesis causes human diseases, such as Diamond-Blackfan anemia, del (5q-) syndrome and bone marrow failure. However, the mechanisms of blood disorders in these diseases remain elus...
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Article
Size Dependence of Nanoparticle-SERS Enhancement from Silver Film over Nanosphere (AgFON) Substrate
The dependence of nanoparticle size on surface-enhanced Raman scattering (SERS) from silver film over nanospheres substrate is studied. For a range of nanosphere sizes from 430 to 1,500 nm, optimum SERS signal...
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Article
Pseudospectral Modeling of Nano-Optics in Ag Sphere Arrays
We report a Legendre pseudospectral modeling of silver sphere arrays illuminated by light waves. A special feature of the present computation is that the dispersive nature of silver is described by a Drude-Lor...
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Article
A Legendre Pseudospectral Penalty Scheme for Solving Time-Domain Maxwell’s Equations
In this paper we present a Legendre pseudospectral algorithm based on a tensor product formulation for solving the time-domain Maxwell equations. Our approach starts by conducting an analysis for finding well-...
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Article
Real-time observation of trigger factor function on translating ribosomes
The contribution of co-translational chaperone functions to protein folding is poorly understood. Ribosome-associated trigger factor (TF) is the first molecular chaperone encountered by nascent polypeptides in...
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Article
Applications of the finite difference mode solution method to photonic crystal structures
The finite difference waveguide mode solution method, which has been popularly employed in the study of waveguide modes on various optical and dielectric waveguides, is utilized to calculate the modal characte...
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Article
Modelling of optical fibre couplers with weakly fused asymmetrical cross-sections based on superposition of normal modes
Wavelength-flattened optical fibre couplers can be designed by employing guided cores with different dimensions. We perform modelling of such couplers with weakly fused cross-sections based on accurate modal a...
