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Humberto Sánchez
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessA chromatinized origin reduces the mobility of ORC and MCM through interactions and spatial constraint
Chromatin replication involves the assembly and activity of the replisome within the nucleosomal landscape. At the core of the replisome is the Mcm2-7 complex (MCM), which is loaded onto DNA after binding to t...
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Article
Open AccessNucleotide binding halts diffusion of the eukaryotic replicative helicase during activation
The eukaryotic replicative helicase CMG centrally orchestrates the replisome and leads the way at the front of replication forks. Understanding the motion of CMG on the DNA is therefore key to our understandin...
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Article
Open AccessDNA replication origins retain mobile licensing proteins
DNA replication in eukaryotes initiates at many origins distributed across each chromosome. Origins are bound by the origin recognition complex (ORC), which, with Cdc6 and Cdt1, recruits and loads the Mcm2-7 (...
