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Article
Open AccessCell-free biosynthesis and engineering of ribosomally synthesized lanthipeptides
Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a major class of natural products with diverse chemical structures and potent biological activities. A vast majority of RiPP gene ...
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Article
Correction: Microglial Depletion does not Affect the Laterality of Mechanical Allodynia in Mice
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Article
Microglial Depletion does not Affect the Laterality of Mechanical Allodynia in Mice
Mechanical allodynia (MA), including punctate and dynamic forms, is a common and debilitating symptom suffered by millions of chronic pain patients. Some peripheral injuries result in the development of bilate...
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Article
Open AccessPreimplantation genetic testing for Aicardi–Goutières syndrome induced by novel compound heterozygous mutations of TREX1: an unaffected live birth
Aicardi–Goutières syndrome (AGS) is a rare, autosomal recessive, hereditary neurodegenerative disorder. It is characterized mainly by early onset progressive encephalopathy, concomitant with an increase in int...
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Article
Parthenolide inhibits proliferation of cells infected with Kaposi’s sarcoma-associated herpesvirus by suppression of the NF-κB signaling pathway
The disease caused by Kaposi’s sarcoma-associated herpesvirus (KSHV) is one of the major causes of death of individuals with acquired immunodeficiency syndrome (AIDS). Development of anti-KSHV drugs is thus cr...
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Article
Completeness-Resolvable Graphs
Given a connected graph \(G=(V(G), E(G))\) G = ...
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Article
Open AccessEWSR1-BEND2 fusion defines an epigenetically distinct subtype of astroblastoma
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Protocol
A Streptomyces-Based Cell-Free Protein Synthesis System for High-Level Protein Expression
With the rapid development of cell-free biotechnology, more and more cell-free protein synthesis (CFPS) systems have been established and optimized for protein expression in vitro. Here, we aim to improve the ...
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Article
Open AccessKaposi’s sarcoma-associated herpesvirus infection promotes proliferation of SH-SY5Y cells by the Notch signaling pathway
The cancer caused by Kaposi’s sarcoma-associated herpesvirus (KSHV) infection is one of the major causes of death in AIDS patients. Some patients have neurological symptoms, which appear to be associated with ...
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Article
Open AccessMolecular and genomic characterisation of a panel of human anal cancer cell lines
Anal cancer is a rare disease that has doubled in incidence over the last four decades. Current treatment and survival of patients with this disease has not changed substantially over this period of time, due,...
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Article
TRESK Regulates Gm11874 to Induce Apoptosis of Spinal Cord Neurons via ATP5i Mediated Oxidative Stress and DNA Damage
Reportedly, TWIK-related spinal cord K+ (TRESK) deficiency in spinal cord neurons positively correlates with the mechanism underlying neuropathic pain (NP). However, the precise effects of TRESK on neurons of the...
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Chapter
Adversarial Defenses on Graphs: Towards Increasing the Robustness of Algorithms
Graph Neural Networks (GNNs) have achieved tremendous development on perceptual tasks in recent years, such as node classification, graph classification, link prediction, community detection and so on. However...
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Article
Open AccessD6 blastocyst transfer on day 6 in frozen-thawed cycles should be avoided: a retrospective cohort study
There is no definitive evidence about the suitable timing to transfer blastocysts formed and cryopreserved on day 6 (D6 blastocysts) in frozen-thawed embryo transfer (FET) cycles. This study aimed to investiga...
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Article
Open AccessIdentification of E2 with improved secretion and immunogenicity against CSFV in piglets
Outbreaks of Classical swine fever virus (CSFV) cause significant economic losses in the swine industry. Vaccination is the major method to prevent and control the disease. As live attenuated vaccines fail to ...
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Article
Potentially actionable FGFR2 high-level amplification in thymic sebaceous carcinoma
Our aim was to investigate sebaceous differentiation in thymus tumours and to identify new actionable genomic alterations. To this end we screened 35 normal and 23 hyperplastic thymuses, 127 thymomas and 41 th...
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Article
“They Have It Better There”: Chinese Immigrant Teachers’ Beliefs, Ideologies and Imaginaries in Cross-National Comparisons
This paper was written in response to a growing need to address the perceptions and experiences of immigrant teachers. Based on a critical intercultural theoretical perspective, which moves beyond typical “cul...
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Article
Open AccessEmergence of Two different recombinant PRRSV strains with low neutralizing antibody susceptibility in China
PRRSV causes major economic loss in global swine industry. 41 of 131 (31.29%) tissue samples collected from pig farms in central and east China from 2016 to 2017 were confirmed as PRRSV positive in RT-PCR. Bas...
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Article
Open AccessSDH-deficient renal cell carcinoma associated with biallelic mutation in succinate dehydrogenase A: comprehensive genetic profiling and its relation to therapy response
Succinate dehydrogenase (SDH)-deficient renal cell carcinoma (RCC) is a rare RCC subtype that is caused by biallelic mutation of one of the four subunits of the SDH complex (SDHA, B, C, and D) and results in inac...
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Article
Non-fragile finite-time filter design for time-delayed Markovian jum** systems via T–S fuzzy model approach
In this paper, the non-fragile finite-time filtering problem is studied for a class of nonlinear Markovian jum** systems (NMJSs) with time delays and uncertainties. To design the mode-dependent non-fragile s...
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Article
Analysis and design of unknown input observers for a class of 2-D nonlinear systems
This paper considers the analysis and design of asymptotic unknown input observers (UIOs) for a class of two-dimensional (2-D) nonlinear systems. A sufficient condition for the existence of an asymptotic UIO s...
