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Article
The high level food-grade expression of glutamate decarboxylase in Bacillus subtilis through combination of genomic integration and free plasmid
γ-Aminobutyric acid (GABA) is a bioactive compound with diverse physiological functions. It has a wide range of applications in food and medicine and mainly biosynthesized through glutamate decarboxylase (GAD)...
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Article
High On-Treatment Platelet Reactivity as Predictor of Long-term Clinical Outcomes in Stroke Patients with Antiplatelet Agents
The purpose was to explore the value of high on-treatment platelet reactivity (HTPR) in predicting long-term clinical outcomes for stroke patients. The platelet reactivity was assayed after being treated with ...
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Article
Enhancement of FK520 production in Streptomyces hygroscopicus by combining traditional mutagenesis with metabolic engineering
FK520 (ascomycin), a 23-membered macrolide with immunosuppressive activity, is produced by Streptomyces hygroscopicus. The problem of low yield and high impurities (mainly FK523) limits the industrialized product...