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Open AccessChemical constituents of industrial hemp roots and their anti-inflammatory activities
Although the chemical constituents of the aerial parts of Cannabis have been extensively studied, phytochemicals of Cannabis roots are not well characterized. Herein, we investigated the chemical constituents of ...
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Article
Open AccessIdentification of a binding site on soluble RANKL that can be targeted to inhibit soluble RANK-RANKL interactions and treat osteoporosis
One of the major challenges for discovering protein-protein interaction inhibitors is identifying selective and druggable binding sites at the protein surface. Here, we report an approach to identify a small m...
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Open AccessAuthor Correction: Inhibitory mechanism of reveromycin A at the tRNA binding site of a class I synthetase
A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-22942-2
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Open AccessAuthor Correction: AdipoR1/AdipoR2 dual agonist recovers nonalcoholic steatohepatitis and related fibrosis via endoplasmic reticulum-mitochondria axis
A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-22414-7
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Article
Open AccessInhibitory mechanism of reveromycin A at the tRNA binding site of a class I synthetase
The polyketide natural product reveromycin A (RM-A) exhibits antifungal, anticancer, anti-bone metastasis, anti-periodontitis and anti-osteoporosis activities by selectively inhibiting eukaryotic cytoplasmic i...
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Article
Open AccessAdipoR1/AdipoR2 dual agonist recovers nonalcoholic steatohepatitis and related fibrosis via endoplasmic reticulum-mitochondria axis
Chronic nonalcoholic steatohepatitis (NASH) is a metabolic disorder that often leads to liver fibrosis, a condition with limited therapy options. Adiponectin is an adipocytokine that regulates glucose and lipi...
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Article
Open AccessA multifunctional DNA nano-scorpion for highly efficient targeted delivery of mRNA therapeutics
The highly efficient cancer cell targeted delivery plays an important role in precise targeted therapies. Herein, a multifunctional DNA nano-scorpion nanostructure (termed AptDzy-DNS) functioned with aptamers ...
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Open AccessPublisher Correction: Double mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid
In the original version of this Article, extraneous text not belonging to the article was accidentally appended to end of the first paragraph of the discussion. This error has now been corrected in both the PD...
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Open AccessDouble mimicry evades tRNA synthetase editing by toxic vegetable-sourced non-proteinogenic amino acid
Hundreds of non-proteinogenic (np) amino acids (AA) are found in plants and can in principle enter human protein synthesis through foods. While aminoacyl-tRNA synthetase (AARS) editing potentially provides a m...
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Open AccessMembrane binding of the insertion sequence of Proteus vulgaris L-amino acid deaminase stabilizes protein structure and increases catalytic activity
Proteus vulgaris L-amino acid deaminase (pvLAAD) belongs to a class of bacterial membrane-bound LAADs mainly express in genus Proteus, Providencia and Morganella. These LAADs employ a non...
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Correction: Corrigendum: CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase
Nature 526, 710–714 (2015); doi:10.1038/nature15510. The Acknowledgements of this Letter should have included the following sentence: “This work was also supported in part by the University of Antwerp (TOP BOF...
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CMT2D neuropathy is linked to the neomorphic binding activity of glycyl-tRNA synthetase
Charcot–Marie–Tooth diseases are hereditary peripheral neuropathies for which there are currently no effective therapies; here the type 2D subtype of these diseases is shown to be caused by mutations impeding ...
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ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase
The crystal structure of prolyl tRNA synthetase simultaneously bound to its substrate ATP and its inhibitor halofuginone, a derivative of a compound used to treat malaria, indicates that (through interactions ...
